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2021 , Vol. 41 >Issue 6: 2217 - 2227

DOI: https://doi.org/10.6023/cjoc202012053

综述与进展

天然药物小檗碱的化学合成研究进展

  • 严锡飞 ,
  • 郑剑峰 ,
  • 李卫东
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  • a 西南交通大学生命科学与工程学院 四川省天然药物仿生合成工程研究中心 成都 610031
    b 伊犁师范大学 新疆天然产物化学与应用重点实验室 新疆伊宁 835000

收稿日期: 2020-12-31

  修回日期: 2021-01-26

  网络出版日期: 2021-02-26

基金资助

国家自然科学基金(21901215); 国家自然科学基金(21672030); 中央高校基本科研业务费专项资金(2682020CX53)

收起

Studies on the Chemical Synthesis of Natural Drugs Berberine

  • Xifei Yan ,
  • Jianfeng Zheng ,
  • Wei-Dong Z. Li
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  • a Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key Laboratory of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining, Xinjiang 835000
*Corresponding authors.E-mail:;

Received date: 2020-12-31

  Revised date: 2021-01-26

  Online published: 2021-02-26

Supported by

National Natural Science Foundation of China(21901215); National Natural Science Foundation of China(21672030); Fundamental Research Funds for the Central Universities(2682020CX53); Key Program of Natural Science Foundation of Xinjiang Autonomous Region Colleges(XJEDU2018I018)

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摘要

小檗碱(Berberine, BBR)是一种重要的天然药物, 是具有独特四环结构的异喹啉类生物碱. 近年来药理学研究发现, 小檗碱有望用于肿瘤及糖尿病等多发病的临床治疗. 结合Woodward等提出的生源合成理论, 综述了截至目前已报道的小檗碱的全合成策略与方法.

关键词： 天然药物; 小檗碱; 苄基异喹啉; 全合成

本文引用格式

严锡飞 , 郑剑峰 , 李卫东 . 天然药物小檗碱的化学合成研究进展[J]. 有机化学, 2021 , 41(6) : 2217 -2227 . DOI: 10.6023/cjoc202012053

Abstract

Berberine is an important natural drug and a kind of benzyl isoquinoline alkaloid, which has unique four-ring structure. In recent years, pharmacological research has found berberine is expected to be used in the clinical treatment of cancer, diabetes and other frequently occurring diseases. Based on the Woodward’s biosynthetic hypothesis, a schematic review on the synthetic studies towards berberine is provided.

Key words： natural drug; berberine; benzyl isoquinoline; total synthesis

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