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2021 , Vol. 41 >Issue 6: 2326 - 2334

DOI: https://doi.org/10.6023/cjoc202012028

研究论文

水相中电化学促进铜催化苯甲醇氧化合成喹唑啉酮

  • 吴媚 ,
  • 于玲 ,
  • 侯慧青 ,
  • 陈厚铮 ,
  • 庄庆龙 ,
  • 周孙英 ,
  • 林小燕
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  • a 福建医科大学药学院 福州 350004
    b 邢台学院 河北邢台 054001

收稿日期: 2020-12-18

  修回日期: 2021-03-03

  网络出版日期: 2021-03-22

基金资助

福建省自然科学基金(2015MP008); 福建省自然科学基金(2017J01820); 福建医科大学启航基金(2018QH2021)

收起

Electrochemistry-Enabled Copper-Catalyzed Oxidation of Benzyl Alcohols for the Preparation of Quinazolinones in Water

  • Mei Wu ,
  • Ling Yu ,
  • Huiqing Hou ,
  • Houzheng Chen ,
  • Qinglong Zhuang ,
  • Sunying Zhou ,
  • Xiaoyan Lin
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  • a Department of Pharmacy, Fujian Medical University, Fuzhou 350004
    b Xingtai University, Xingtai, Hebei 054001
*Corresponding author.E-mail:

Received date: 2020-12-18

  Revised date: 2021-03-03

  Online published: 2021-03-22

Supported by

Natural Science Foundation of Fujian Province(2015MP008); Natural Science Foundation of Fujian Province(2017J01820); and the Fujian Medical University Sailing Foundation(2018QH2021)

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摘要

喹唑啉酮类化合物是一种重要的含氮杂环化合物, 也是多种天然产物以及合成药物的骨架分子. 利用廉价易得的苯甲醇以及邻氨基苯甲酰胺为原料, 通过CuCl2和电流共同氧化苯甲醇, 在室温条件下于水相中一锅法合成喹唑啉酮及其衍生物, 目标化合物可获得中等至优秀的产率. 该方法用电流代替价格昂贵、毒性大的氧化剂, 为合成喹唑啉酮类化合物提供了一条操作简便、绿色可持续的合成途径.

关键词： 电合成; 喹唑啉酮; 绿色化学; 铜催化剂; 水相

本文引用格式

吴媚 , 于玲 , 侯慧青 , 陈厚铮 , 庄庆龙 , 周孙英 , 林小燕 . 水相中电化学促进铜催化苯甲醇氧化合成喹唑啉酮[J]. 有机化学, 2021 , 41(6) : 2326 -2334 . DOI: 10.6023/cjoc202012028

Abstract

Quinazolinone is one of the most important nitrogen-containing heterocyclic compound, which is widely found in numerous natural products and synthetic drugs. Quinazolinone derivatives were synthesized by one-pot co-oxidation of benzyl alcohol with CuCl2 and electric current in aqueous phase. The reaction provides an efficient protocol to a series of quinazolinones derivatives in good to high yields. This synthesis process features convenient operation and environmental friendliness, which make it a promising method for the preparation of quinazolinone derivatives insteading of expensive and toxic oxidants with electric current.

Key words： electrochemistry; quinazolinone; green chemistry; copper catalysis; water

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