诺丽酵素中两个新的酚类衍生物及其α-葡萄糖苷酶抑制活性
收稿日期: 2021-01-04
修回日期: 2021-03-18
网络出版日期: 2021-04-06
基金资助
海南省重点研发项目(ZDYF2019165); 教育部创新研究团队项目(IRT-16R19); 国家自然科学基金(21662012); 国家自然科学基金(4186605); 海南医学院热带转化医学教育部重点实验室的开放基金(2020TTM001); 海南省研究生创新研究(Hyb2020-54)
Two New Phenolic Derivatives withα-Glucosidase Inhibitory Activities fromNoni Juice
Received date: 2021-01-04
Revised date: 2021-03-18
Online published: 2021-04-06
Supported by
Key Research and Development Project of Hainan Province(ZDYF2019165); Innovative Research Team Project of Ministry of Education(IRT-16R19); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(4186605); Open Foundation of Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University(2020TTM001); Innovative Research Projects of Postgraduates in Hainan Universities(Hyb2020-54)
从诺丽酵素中分离纯化得到两个新的酚类衍生物Noniacid A (1), Noniacid B (2)和一个新天然产物Melilotic acid (3), 它们的结构通过多种现代波谱技术进行确定.α-葡萄糖苷酶抑制活性测试结果显示, 化合物1和2对α-葡萄糖苷酶具有较强的抑制活性, IC50值分别为242.0和229.3 µmol•L–1.
关键词： 诺丽酵素; 酚类衍生物; α-葡糖苷酶抑制活性
张斌 , 周学明 , 余章昕 , 李小宝 , 易继凌 , 黄柯蕾 , 唐春美 , 刘晴 , 陈光英 . 诺丽酵素中两个新的酚类衍生物及其α-葡萄糖苷酶抑制活性[J]. 有机化学, 2021 , 41(7) : 2910 -2913 . DOI: 10.6023/cjoc202101006
Two new lactic acid derivatives of noniacids A and B (1 and 2) and a new natural product melilotic acid (3) were obtained from the ethyl acetate extract of theNoni Juice. The structures were elucidated using comprehensive spectroscopic methods, and the absolute configurations were defined by comparing optical rotation with the standard. Compounds 1 and 2 showed significant inhibitory activity againstα-glucosidase enzyme with IC50 values of 242.0 and 229.3 µmol•L–1, respectively.
Key words： Noni Juice; phenolic derivatives; α-glucosidase activity
| [1] | Sang,S. M.; Cheng,X. F.; Zhu,N. Q.; Stark,R. E.; Badmaev, V.; Ghai, G.; Rosen,R. T.; Ho,C. T. J Agric Food Chem, 2001, 49,4478. |
| [2] | Li,F. Y.; Lan,Z. Q.; Liu, CF.; Li,Q. H. J Anhui Agric. Sci. 2009, 37,15819 (in Chinese). |
| [2] | ( 李法营, 蓝增全, 刘昌芬, 李青红, 安徽农业科学, 2009, 37,15819.) |
| [3] | West,B. J.; Tani, H.; Palu,A. K.; Tolson,C. B.; Jensen,C. J.S. J Sci. Food Agric. 2010, 87,2583. |
| [4] | Lachenmeier, K.; Masshoff, F.; Madea, B.; Reusch, H.; Lachenmeier,D. W. Dtsch. Lebensm.-Rundsch. 2006, 102,58. |
| [5] | Ali, M.; Kenganora, M.; Manjula,S. N. Pharm. J. 2016, 8,321. |
| [6] | Youn,U. J.; Park,E. J.; Kondratyuk,T. P.; Sang,N. M.; Wall,M. M.; Wei,Y. Z.; Pezzuto,J. M.; Chang,L. C. J. Nat. Prod. 2016, 79,1508. |
| [7] | Youn,U. J.; Chang,L. C. Nat. Prod. Sci. 2017, 23,16. |
| [8] | Zhang, B.; Zhou,X. M.; Zhao, T.; Wang,J. L.; Li,M. M.; Lv, S.; Zhou, Q.; Chen,G. Y. Chin. J. Chin. Mater. Med. 2019, 44,4015 (in Chinese). |
| [8] | ( 张斌, 周学明, 赵婷, 王佳莉, 李苗苗, 吕森, 周琴, 陈光英, 中国中药杂志, 2019, 44,4015.) |
| [9] | Liang,H. Q.; Zhang, L.; Cheng, C.; Chen,J. G. Nat. Prod. Res. Dev. 2018, 30,795 (in Chinese). |
| [9] | ( 梁寒峭, 张露, 程池, 陈建国, 天然产物研究与开发, 2018, 30,795.) |
| [10] | Nayak,B. S.; Marshall,J. R.; Isitor, G.; Adogwa, A. J. Evidence-Based Complementary Altern. Med. 2011,875293. |
| [11] | Chang,Y. Y.; Lin,Y. L.; Yang,D. J.; Liu,C. W.; Hsu,C. L.; Tzang,B. S.; Chen,Y. C. J. Agric. Food Chem. 2013, 61,11016. |
| [12] | Lin,Y. L.; Chen,Y. C.; Lin,H. W.; Yang,D. J.; Li,C. C.; Chang,Y. Y. J. Chin. Med. Assoc. 2017, 80,212. |
| [13] | Cao,B. C.; Xu,J. L. Food Ferment. Ind. 1993, 3,56 (in Chinese). |
| [13] | ( 曹本昌, 徐建林, 食品与发酵工业, 1993, 3,56.) |
| [14] | Grasso, S.; Siracusa, L.; Spatafora, C.; Renis, M.; Tringali, C. Bioorg. Chem. 2007, 35,137. |
| [15] | Kuang, X.; Yang,J. Y.; Cai, J.; Liao,Q. Y.; Liao, S.; Zhou,X. M. Chin. Tradit. Herb. Drugs 2019, 42,2557 (in Chinese). |
| [15] | ( 匡鑫, 杨静雨, 蔡瑾, 廖启英, 廖珊, 周学明, 中药材, 2019, 42.2557.) |
| [16] | Moore,C. W. Proc. Chem. Soc.,London 1911, 27,119. |
| [17] | Ma, K.; Han,J. J.; Bao, L.; Wei,T. Z.; Liu,H. W. J. Nat. Prod. 2014, 77,942. |
| [18] | Wu,J. T.; Zheng,C. J.; Zhang, B.; Zhou,X. M.; Zhou, Q.; Chen,G. Y.; Zeng,Z. E.; Xie,J. L.; Han,C. R.; Lyu,J. X. Nat. Prod. Res. 2019, 33.34. |
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