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2021 , Vol. 41 >Issue 7: 2810 - 2819

DOI: https://doi.org/10.6023/cjoc202102037

研究论文

铜催化合成2-亚氨基-1,2-二氢喹啉化合物

  • 祝改革 ,
  • 赖晓辉 ,
  • 王思雨 ,
  • 林彩霞 ,
  • 袁耀锋
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  • 福州大学化学学院 福州 350108

收稿日期: 2021-02-21

  修回日期: 2021-03-23

  网络出版日期: 2021-04-12

基金资助

国家自然科学基金(21772023); 国家自然科学基金(22071025)

收起

Synthesis of 2-Imino-1,2-dihydroquinolines via Copper Catalysis

  • Gaige Zhu ,
  • Xiaohui Lai ,
  • Siyu Wang ,
  • Caixia Lin ,
  • Yaofeng Yuan
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  • College of Chemistry, Fuzhou University, Fuzhou 350108
* Corresponding authors. E-mail: ;

Received date: 2021-02-21

  Revised date: 2021-03-23

  Online published: 2021-04-12

Supported by

National Natural Science Foundation of China(21772023); National Natural Science Foundation of China(22071025)

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摘要

报道了室温条件下磺酰叠氮、2-氨基苯甲醛、末端炔烃通过一价铜催化合成2-亚氨基-1,2-二氢喹啉化合物的方法. 该反应条件温和, 具有较好的底物普适性, 当更改底物炔烃的类型时, 可以选择控制不同产物的合成, 包括二氢喹啉和N-磺酰脒类化合物.

关键词： 2-亚氨基-1; 2-二氢喹啉; 三组分反应; 磺酰叠氮; 炔烃

本文引用格式

祝改革 , 赖晓辉 , 王思雨 , 林彩霞 , 袁耀锋 . 铜催化合成2-亚氨基-1,2-二氢喹啉化合物[J]. 有机化学, 2021 , 41(7) : 2810 -2819 . DOI: 10.6023/cjoc202102037

Abstract

A mild three-component method for the synthesis of 2-imino-1,2-dihydroquinoline compounds has been successfully developed. In the presence of CuCl, various terminal alkynes, sulfonyl azides and 2-aminobenzaldehydes were coupled. When changing the type of substrate alkyne, controlled synthesis of dihydroquinoline and sulfonyl amidine compounds were achieved.

Key words： 2-imino-1; 2-dihydroquinoline; three-component synthesis; sulfonyl azides; alkynes

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