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2021 , Vol. 41 >Issue 7: 2898 - 2904

DOI: https://doi.org/10.6023/cjoc202102029

研究简报

毛华菊中倍半萜内酯类化学成分研究

  • 刘文琪 ,
  • 佘嘉祎 ,
  • 杨英 ,
  • 朱世明 ,
  • 熊校勤 ,
  • 谭芬 ,
  • 张洪权 ,
  • 杨新洲 ,
  • 曾国平
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  • a 湖北第二师范学院化学与生命科学学院 武汉 430205
    b 植物抗癌活性物质提纯与应用湖北省重点实验室 武汉 430205
    c 中南民族大学药学院 武汉 430074
† 共同第一作者(These authors contributed equally to this work).

收稿日期: 2021-02-17

  修回日期: 2021-03-26

  网络出版日期: 2021-04-25

基金资助

国家自然科学基金(21602052); 国家自然科学基金(81903115); 湖北省教育厅科学技术研究(B2019178); 湖北省大学生创新创业训练计划(S202014099006)

收起

Sesquiterpene Lactones fromDendranthema vestitum(Hemsl.) Ling

  • Wenqi Liu ,
  • Jiayi She ,
  • Ying Yang ,
  • Shiming Zhu ,
  • Xiaoqin Xiong ,
  • Fen Tan ,
  • Hongquan Zhang ,
  • Xinzhou Yang ,
  • Guoping Zeng
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  • a Department of Chemistry and Life Science, Hubei University of Education, Wuhan 430205
    b Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Wuhan 430205
    c College of Pharmacy, South-Central University for Nationalities, Wuhan 430074
* Corresponding authors. E-mail: ;
;

Received date: 2021-02-17

  Revised date: 2021-03-26

  Online published: 2021-04-25

Supported by

National Natural Science Foundation of China(21602052); National Natural Science Foundation of China(81903115); Science Research Project of Hubei Provincial Department of Education(B2019178); Undergraduate Innovation and Entreoreneurship Training Progam of Hubei Province(S202014099006)

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摘要

采用溶剂提取法, Diaion HP-20、Sephadex LH-20葡聚糖凝胶、硅胶及制备高效液相等色谱方法, 对毛华菊的化学成分进行分离纯化, 并利用现代波谱技术对已分离得到的化合物进行结构鉴定. 从毛华菊的氯仿部位分离得到4个新化合物, 其结构类型属于愈创木内酯衍生物, 分别命名为(1S,5R,6S,7S,10S)-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(1)、(1S,5R,6R,7R,8S,10S)-8-异丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(2)、(1S,5R,6R,7R,8S,10S)-8-(2'-甲基)丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(3)和(1R,5R,6R,7R,8S,10S,11S)-8-乙酰氧基-愈创木-3-烯-2-酮-12,6-内酯(4), 以及2个已知化合物matricarin (5)和11,13-dehydromatricarin (6).

关键词： 毛华菊; 倍半萜内酯; 愈创木内酯

本文引用格式

刘文琪 , 佘嘉祎 , 杨英 , 朱世明 , 熊校勤 , 谭芬 , 张洪权 , 杨新洲 , 曾国平 . 毛华菊中倍半萜内酯类化学成分研究[J]. 有机化学, 2021 , 41(7) : 2898 -2904 . DOI: 10.6023/cjoc202102029

Abstract

The chemical constituents fromDendranthema vestitum(Hemsl.) Ling were isolated and purified by solvent extraction, Diaion HP-20, Sephadex LH-20, silica gel and preparative high performance liquid chromatography. Their structures were elucidated based on their spectroscopic data. Four new compounds which belong to guaianolide, named as (1S,5R,6S, 7S,10S)-2-oxo-guaia-3,11(13)-dien-12,6-olide (1), (1S,5R,6R,7R,8S,10S)-2-oxo-8-isobutyryloxy-guaia-3,11(13)-dien-12,6-oli- de (2), (1S,5R,6R,7R,8S,10S)-2-oxo-8-(2'-methyl)butyryloxy-guaia-3,11(13)-dien-12,6-olide (3) and (1R,5R,6R,7R,8S,10S, 11S)-2-oxo-8-acetoxy-guaia-3-en-12,6-olide (4) together with two known compounds matricarin (5) and 11,13-dehydromatricarin (6) were isolated from chloroform extract ofDendranthema vestitum(Hemsl.) Ling.

Key words： Dendranthema vestitum(Hemsl.) Ling; sesquiterpene lactones; guaianolide

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