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2021 , Vol. 41 >Issue 8: 3242 - 3248

DOI: https://doi.org/10.6023/cjoc202102007

研究论文

铜催化2-羟基芳基烯胺酮经三氟甲基自由基加成串联环化反应合成3-三氟甲基色酮

  • 杜科莹 ,
  • 张展铭 ,
  • 盛卫坚
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  • 浙江工业大学化学工程学院 杭州 310014

收稿日期: 2021-02-01

  修回日期: 2021-03-16

  网络出版日期: 2021-05-08

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Copper-Catalyzed the Synthesis of 3-Trifluoromethylchromone via Trifluoromethyl Radical Addition Tandem Cyclization Reaction of 2-Hydroxyphenyl Enaminones

  • Keying Du ,
  • Zhanming Zhang ,
  • Weijian Sheng
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  • College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
*Corresponding author.E-mail:

Received date: 2021-02-01

  Revised date: 2021-03-16

  Online published: 2021-05-08

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摘要

色酮化合物因其独特的骨架结构在抗肿瘤、抗菌和抗炎等方面表现出很强的药物活性. 以Cu(OAc)2为催化剂, CF3SO2Na为三氟甲基自由基源, 过氧化叔丁醇(TBHP)为氧化剂, 2-羟基苯基烯胺酮经自由基加成串联环化反应合成了3-三氟甲基色酮, 反应条件温和, 烯胺酮底物具有良好的普适性.

关键词： 自由基加成; 三氟甲基; 烯胺酮; 色酮

本文引用格式

杜科莹 , 张展铭 , 盛卫坚 . 铜催化2-羟基芳基烯胺酮经三氟甲基自由基加成串联环化反应合成3-三氟甲基色酮[J]. 有机化学, 2021 , 41(8) : 3242 -3248 . DOI: 10.6023/cjoc202102007

Abstract

Chromones have shown strong drug activity in anti-tumor, antibacterial and anti-inflammatory aspects for their unique skeleton structure. Using Cu(OAc)2 as catalyst, CF3SO2Na as trifluoromethyl radical source, tert-butanol peroxide (TBHP) as oxidant, 3-trifluoromethylchromone was synthesized by radical addition tandem cyclization reaction of 2-hydroxyphenyl enaminone under mild reaction conditions, and enaminone substrate has good functional tolerance.

Key words： radical addition; trifluoromethyl; enaminone; chromones

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