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2021 , Vol. 41 >Issue 11: 4415 - 4420

DOI: https://doi.org/10.6023/cjoc202106003

研究论文

深共融溶剂中Baeyer缩合反应合成三芳基甲烷衍生物

  • 乐长高 ,
  • 胡智宇 ,
  • 陈学华 ,
  • 鄢丽媛 ,
  • 刘一帅 ,
  • 谢宗波
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  • 东华理工大学 江西省合成化学重点实验室 江西南昌 330013

收稿日期: 2021-06-02

  修回日期: 2021-07-27

  网络出版日期: 2021-08-10

基金资助

国家自然科学基金(11765002)

收起

Synthesis of Triarylmethane Derivatives by Baeyer Condensation in a Deep Eutectic Solvent

  • Zhanggao Le ,
  • Zhiyu Hu ,
  • Xuehua Chen ,
  • Liyuan Yan ,
  • Yishuai Liu ,
  • Zongbo Xie
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  • Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang, Jiangxi 330013
* Corresponding author. E-mail:

Received date: 2021-06-02

  Revised date: 2021-07-27

  Online published: 2021-08-10

Supported by

National Natural Science Foundation of China(11765002)

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摘要

三芳基甲烷及其衍生物在纺织、医药等领域被广泛应用, 有关它的高效合成方法备受研究者的关注. 本研究选用了绿色的深共融溶剂[ChCl][ZnCl2]协同促进苯甲醛与N-取代苯胺之间的Baeyer缩合反应, 高效地合成了多种三芳基甲烷衍生物. 该方法采用了深共融溶剂作为催化剂和绿色反应介质, 无需额外添加催化剂, 仅用几个小时就能得到目标产物. 此外, 深共融溶剂在此过程中重复使用了多次, 且没有明显的活性损失.

关键词： 三芳基甲烷衍生物; 深共融溶剂; Baeyer缩合; 绿色化学

本文引用格式

乐长高 , 胡智宇 , 陈学华 , 鄢丽媛 , 刘一帅 , 谢宗波 . 深共融溶剂中Baeyer缩合反应合成三芳基甲烷衍生物[J]. 有机化学, 2021 , 41(11) : 4415 -4420 . DOI: 10.6023/cjoc202106003

Abstract

Triarylmethane derivatives and their syntheses are of great interest owing to their broad applicability in areas from textiles to medicine. In this study, the green solvent [ChCl][ZnCl2] synergistically promoted Baeyer condensation between benzaldehyde and N-substituted aniline to efficiently synthesize triarylmethane derivatives with high para-selectivity. The employed deep eutectic solvent acted as both a catalyst and green reaction medium for the reaction. Moreover, the deep eutectic solvent was reused several times in this procedure without significant loss of activity.

Key words： triarylmethane derivatives; deep eutectic solvents; Baeyer condensation; green chemistry

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