CBr4促进的分子间环化反应: 高效合成取代N-酰基吡唑
收稿日期: 2021-07-07
修回日期: 2021-07-26
网络出版日期: 2021-08-25
基金资助
延安大学博士科研启动基金(YDBK2019-30); 延安市高层次人才专项基金(2019-29); 陕西省教育厅自然科学专项研究基金(21JK0979); 陕西省科技资源开放共享平台(2021PT-004); 陕西省教育厅重点科学研究计划(20JS154); 山东省自然科学基金(ZR2020QB042)
CBr4-Mediated Intermolecular Cyclization Reaction: Efficient Synthesis of Substituted N-Acylpyrazoles
Received date: 2021-07-07
Revised date: 2021-07-26
Online published: 2021-08-25
Supported by
PhD Research Startup Foundation o Yan'an University(YDBK2019-30); Municipal Special Fund of Yan'an for High-Level Talents(2019-29); Scientific Research Program Funded by Shaanxi Provincial Education Department(21JK0979); Open Sharing Platform for Scientific and Technological Resources of Shaanxi Province(2021PT-004); Key Scientific Research Project of Shaanxi Provincial Education Department(20JS154); Natural Science Foundation of Shandong Province(ZR2020QB042)
马豪杰 , 孙洲 , 刘金磊 , 张夏 , 崔华莉 , 张玉琦 , 王记江 . CBr4促进的分子间环化反应: 高效合成取代N-酰基吡唑[J]. 有机化学, 2021 , 41(11) : 4353 -4360 . DOI: 10.6023/cjoc202107020
Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl)(phenyl)-methanones in excellent yields by CBr4 mediated intermolecular cyclization of benzohydrazide and pentane-2,4-dione has been reported. The method shows various advantages such as mild conditions, good functional group tolerance, environmental friendliness, easy operation with cheap reagents, step economy and can be scaled-up, offering a useful and attractive strategy to synthesize N-acylpyrazoles, which is widely presented in drugs, biologically active molecules and pesticides.
Key words： benzohydrazides; pentane-2,4-diones; N-acylpyrazoles; CBr4
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