氮杂环卡宾催化构筑含七元环结构的研究进展
收稿日期: 2021-09-14
修回日期: 2021-11-16
网络出版日期: 2021-12-02
基金资助
北京市自然科学基金(2212009); 国家自然科学基金(22171027); 北京师范大学启动经费(312232112)
Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes
Received date: 2021-09-14
Revised date: 2021-11-16
Online published: 2021-12-02
Supported by
Beijing Natural Science Foundation(2212009); National Natural Science Foundation of China(22171027); Beijing Normal University Startup Funding(312232112)
七元环作为重要的结构单元广泛存在于多种天然产物、活性化合物和药物分子中. 与五、六元环结构相比, 七元环的构筑更具挑战性, 且合成方法相对较少. 因此, 发展高效构筑七元环结构的方法具有重要意义. 氮杂环卡宾(NHC)为重要的有机催化剂, 其共价催化特性为高效构筑多种新颖手性结构提供了独特方法. 尽管该领域已取得重要进展, 然而, 目前大量研究仍集中于构筑五、六元环结构. 综述了近年来利用NHC催化策略构筑七元环结构的研究进展. 通过对NHC催化构筑七元环结构合成策略的总结, 旨在启发从事相关领域的合成化学家发展更多高效构筑七元环的新策略.
姚婷 , 李佳燕 , 王佳明 , 赵常贵 . 氮杂环卡宾催化构筑含七元环结构的研究进展[J]. 有机化学, 2022 , 42(4) : 925 -944 . DOI: 10.6023/cjoc202109020
The seven-membered rings represent an important structural motif and have found wide presence in natural products, biologically active molecules and drugs. In contrast to the five- and six-membered rings, the construction of seven- membered ring remains challenging. Thus, the developing efficient strategies for the synthesis of seven-membered rings is very desirable. N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful and unique tool for the quick construction of complex molecular architectures. Nevertheless, whereas significant advances have been made using NHC as catalysis. However, most of these works concentrated on the assembly of five or six-membered rings. This review highlights the developments and new advances for the construction of seven-membered rings catalyzed by NHC. The aim of this review is to provide an overview of this area and inspire synthetic chemists to develop more efficient and novel strategies for the construction of seven-membered rings.
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