诺丽酵素中两个新的曲酸类化合物对胰岛素抵抗HepG2细胞葡萄糖摄取的影响
收稿日期: 2021-10-05
修回日期: 2021-11-23
网络出版日期: 2021-12-15
基金资助
海南省重点研发计划(ZDYF2019116); 国家自然科学基金(41866005); 国家自然科学基金(22177023)
Two New Kojic Acids from Noni Juice with Glucose Uptake Activity in Insulin-Resistant HepG2 Cells
Received date: 2021-10-05
Revised date: 2021-11-23
Online published: 2021-12-15
Supported by
Key Research and Development Project of Hainan Province(ZDYF2019116); National Natural Science Foundation of China(41866005); National Natural Science Foundation of China(22177023)
从诺丽酵素中分离获得两个新的曲酸类化合物nonikojic A (1)和nonikojic B (2), 通过多种现代波谱技术确定了它们的化学结构. 并对这2个化合物进行了胰岛素抵抗HepG2细胞葡萄糖摄取的活性评价, 结果显示化合物1和2在50 μmol/L剂量下均可显著地促进胰岛素抵抗HepG2细胞的葡萄糖摄取, 从而改善胰岛素抵抗.
关键词： 诺丽酵素; 曲酸类化合物; 葡萄糖摄取; 胰岛素抵抗HepG2细胞
张旭光 , 张斌 , 周学明 , 余章昕 , 李小宝 , 陈光英 . 诺丽酵素中两个新的曲酸类化合物对胰岛素抵抗HepG2细胞葡萄糖摄取的影响[J]. 有机化学, 2022 , 42(4) : 1252 -1255 . DOI: 10.6023/cjoc202110006
Two new kojic acids, nonikojics A and B (1 and 2), were obtained from the water soluble extract of the Noni juice, and their chemical structures were elucidated by comprehensive modern spectroscopic techniques. The effects on glucose uptake of two new compounds were evaluated in insulin-resistant HepG2 cells, and the results indicated that 1 and 2 significantly increased glucose uptake with doses of 50 μmol/L and thus improved insulin resistance.
Key words： Noni juice; kojic acids; glucose uptake; insulin-resistant HepG2 cells
| [1] | Zhang, K.; Meng, J.; Li, X. J.; Tang, X.; Ma, S. H.; Lv, Y. P.; Yang, S. J. J. Food Biochem. 2020, 44, e13460. |
| [2] | Li, J.; Niu, D. B.; Zhang, Y.; Zeng, X. A. Int. J. Biol. Macromol. 2020, 150, 114. |
| [3] | Torres, M. A. O.; de Fátima, B. Ma. I.; Mondêgo-Oliveira, R.; de Sá, J. C.; Rocha, A. L.; Abreu-Silva, A. L. Phytother. Res. 2017, 31, 971. |
| [4] | Lin, Y. L.; Chang, Y.; Yang, D. J.; Tzang, B. S.; Chen, Y. C. Food Chem. 2013, 140, 31. |
| [5] | Zhang, K.; Meng, J.; Li, X.; Tang, X.; Ma, S.; Lv, Y.; Yang, S. J. Food Biochem. 2020, 44, e13460. |
| [6] | Zhang, B.; Zhou, X. M.; Yu, Z. X.; Li, X. B.; Yi, J. L.; Huang, K. L.; Tang, C. M.; Liu, Q.; Chen, G. Y. Chin. J. Org. Chem. 2021, 41, 2910. (in Chinese) |
| [6] | ( 张斌, 周学明, 余章昕, 李小宝, 易继凌, 黄柯蕾, 唐春美, 刘晴, 陈光英, 有机化学, 2021, 41, 2910.) |
| [7] | Zhang, B.; Yu, Z. X.; Zhou, X. M.; Nong, X. H.; Li, X. B.; Wang, H.; Wang, H.; Chen, G. Y. Fitoterapia 2021, 153, 104946. |
| [8] | Almeida, É. S.; de Oliveira, D.; Hotza, D. Compr. Rev. Food Sci. Food Saf. 2019, 18, 883. |
| [9] | Dussossoy, E.; Brat, P.; Bony, E.; Boudard, F.; Poucheret, P.; Mertz, C.; Giaimis, J.; Michel, A. J. Ethnopharmacol. 2011, 133, 108. |
| [10] | Singh, B.; Sharma, R. A. Phytother. Res. 2020, 34, 924. |
| [11] | Zhang, B.; Zhou, X. M.; Zhao, T.; Wang, J. L.; Li, M. M.; Lv, S.; Zhou, Q.; Chen, G. Y. China J. Chin. Mater. Med. 2019, 44, 4015. (in Chinese) |
| [11] | ( 张斌, 周学明, 赵婷, 王佳莉, 李苗苗, 吕森, 周琴, 陈光英, 中国中药杂志, 2019, 44, 4015.) |
| [12] | Nguyen, P. H.; Yang, J. L.; Uddin, M. N.; Park, S. L.; Lim, S. I.; Jung, D. W.; Williams, D. R.; Oh, W. K. J. Nat. Prod. 2013, 76, 2080. |
| [13] | Lee, S. Y.; Park, S. L.; Hwang, J. T.; Yi, S. H.; Nam, Y. D.; Lim, S. I. J. Evidence-Based Complementary Altern. Med. 2012, 2012, 163280. |
| [14] | Owen, P. L.; Martineau, L. C.; Caves, D.; Haddad, P. S.; Matainaho, T.; Johns, T. Asia Pac. J. Clin. Nutr. 2008, 17, 635. |
| [15] | Li, T. X.; Meng, D. D.; Wang, Y.; An, J. L.; Bai, J. F.; Jia, X. W.; Xu, C. P. Nat. Prod. Res. 2020, 34, 1360. |
| [16] | Luo, W.; Ai, L.; Wang, B. F.; Zhou, Y. Biomed. Pharmacother. 2019, 120, 109498. |
/
| 〈 |
|
〉 |
