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2022 , Vol. 42 >Issue 5: 1509 - 1519

DOI: https://doi.org/10.6023/cjoc202111009

研究论文

银催化下三氟甲基取代的2-咪唑啉化合物的合成

  • 杨明 ,
  • 黄丹凤 ,
  • 王克虎 ,
  • 韩侗育 ,
  • 赵鹏飞 ,
  • 王凤 ,
  • 王君姣 ,
  • 苏瀛鹏 ,
  • 胡雨来
展开
  • 西北师范大学化学化工学院 兰州 730070

收稿日期: 2021-11-04

  修回日期: 2021-12-30

  网络出版日期: 2022-01-21

基金资助

国家自然科学基金(22061037); 国家自然科学基金(21861033); 上海恩氟佳科技有限公司资助项目

收起

Silver-Catalyzed Synthesis of CF3-Substituted 2-Imidazolines

  • Ming Yang ,
  • Danfeng Huang ,
  • Kehu Wang ,
  • Tongyu Han ,
  • Pengfei Zhao ,
  • Feng Wang ,
  • Junjiao Wang ,
  • Yingpeng Su ,
  • Yulai Hu
Expand
  • College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
*Corresponding authors. E-mail: ;

Received date: 2021-11-04

  Revised date: 2021-12-30

  Online published: 2022-01-21

Supported by

National Natural Science Foundation of China(22061037); National Natural Science Foundation of China(21861033); Shanghai Sinofluoro Chemicals Co., Ltd

Fold

摘要

探索了银盐催化下, 三氟甲基酰腙与异氰基乙酸乙酯的[3+2]环加成反应, 合成了一系列三氟甲基取代的2-咪唑啉化合物. 该方法具有反应速度快、产率高和立体选择性好等特点, 为合成三氟甲基取代的2-咪唑啉类化合物提供了一种快速有效的新方法．

关键词： 三氟甲基酰腙; 异氰基乙酸乙酯; [3+2]环加成; 2-咪唑啉

本文引用格式

杨明 , 黄丹凤 , 王克虎 , 韩侗育 , 赵鹏飞 , 王凤 , 王君姣 , 苏瀛鹏 , 胡雨来 . 银催化下三氟甲基取代的2-咪唑啉化合物的合成[J]. 有机化学, 2022 , 42(5) : 1509 -1519 . DOI: 10.6023/cjoc202111009

Abstract

The silver salt catalyzed [3+2] cycloaddition reaction of trifluoromethylated N-acylhydrazones and ethyl isocyanoacetate was investigated. The reaction proceeds quickly to produce a series of trifluoromethylated 2-imidazoline compounds in high yields with excellent stereoselectivity, which provides a novel and efficient method for the synthesis of trifluoromethylated 2-imidazoline compounds.

Key words： trifluoromethylated N-acylhydrazone; ethyl isocyanoacetate; [3+2] cycloaddition; 2-imidazoline

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