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2022 , Vol. 42 >Issue 5: 1551 - 1556

DOI: https://doi.org/10.6023/cjoc202110007

研究简报

一步法合成1,2,4-三氮唑[3,4-i]嘌呤类化合物

  • 楚治良 ,
  • 陈晖娟 ,
  • 单帅 ,
  • 王晓娜 ,
  • 高春芳 ,
  • 渠桂荣 ,
  • 刘忠于 ,
  • 郭海明
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  • a 中国人民解放军联勤保障部队第989医院 河南洛阳 471031
    b 河南师范大学化学化工学院 河南新乡 453007

收稿日期: 2021-10-08

  修回日期: 2022-01-26

  网络出版日期: 2022-02-10

基金资助

国家自然科学基金(U1604283); 国家科技重大专项(2014ZX09J14101-01A); 洛阳市科技计划医疗卫生(1720001A-8)

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One-Step Synthesis of 1,2,4-Triazolo[3,4-i]purine Derivatives

  • Zhiliang Chu ,
  • Huijuan Chen ,
  • Shuai Shan ,
  • Xiaona Wang ,
  • Chunfang Gao ,
  • Guirong Qu ,
  • Zhongyu Liu ,
  • Haiming Guo
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  • a The 989th Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army, Luoyang, Henan 471031
    b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
*Corresponding authors. E-mail: ;

Received date: 2021-10-08

  Revised date: 2022-01-26

  Online published: 2022-02-10

Supported by

National Natural Science Foundation of China(U1604283); National Science and Technology Major Project(2014ZX09J14101-01A); Medical and Health Project of Luoyang Science and Technology Plan(1720001A-8)

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摘要

1,2,4-三氮唑[3,4-i]嘌呤类化合物是潜在的黄嘌呤氧化酶(XO)抑制剂, 有望用于痛风的治疗. 报道了一种一步合成1,2,4-三氮唑[3,4-i]嘌呤类化合物的新方法. 以6-肼基-N9-取代嘌呤和脂肪族一元羧酸为原料, 无水硫酸镁作除水剂, 合成了17个新化合物. 该方法操作简单, 无需使用其他催化剂和氧化剂, 且收率良好. 同时, 探讨了影响反应的因素, 为1,2,4-三氮唑[3,4-i]嘌呤类化合物研究奠定了基础.

关键词： 6-肼基-N9-取代嘌呤; 脂肪族一元羧酸; 1,2,4-三氮唑[3,4-i]嘌呤类化合物

本文引用格式

楚治良 , 陈晖娟 , 单帅 , 王晓娜 , 高春芳 , 渠桂荣 , 刘忠于 , 郭海明 . 一步法合成1,2,4-三氮唑[3,4-i]嘌呤类化合物[J]. 有机化学, 2022 , 42(5) : 1551 -1556 . DOI: 10.6023/cjoc202110007

Abstract

1,2,4-Triazolo[3,4-i]purine derivatives are potential xanthine oxidase (XO) inhibitors and expected to be used in the treatment of gout. A new one-step method for the preparation of 1,2,4-triazolo[3,4-i]purine derivatives has been reported. Seventeen novel 1,2,4-triazolo[3,4-i]purine derivatives were synthesized with 6-hydrazinyl-N9-substituted purine and aliphatic monocarboxylic acid as starting materials and anhydrous magnesium sulfate as dehydrating agent. The method is easy to operate without using other catalysts and oxidants, and the yield is good. Meanwhile, the factors affecting the reaction were discussed, which laid a foundation for the study of 1,2,4-triazolo[3,4-i]purine compounds

Key words： 6-hydrazinyl-N9-substituted purine; aliphatic monocarboxylic acid; 1,2,4-triazolo[3,4-i]purine derivative

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