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2022 , Vol. 42 >Issue 6: 1770 - 1777

DOI: https://doi.org/10.6023/cjoc202110030

研究论文

可见光催化苯并噁唑与α-酮酸合成芳基苯并噁唑

  • 李亚东 ,
  • 吴鹏举 ,
  • 杨志勇
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  • 贵州理工学院化学工程学院 贵阳 550003

收稿日期: 2021-10-21

  修回日期: 2022-01-04

  网络出版日期: 2022-02-25

基金资助

贵州理工学院高层次人才启动(XJGC20180931); 贵州省科技厅自然科学基金(QKHJZ20152060); 贵州省科技厅自然科学基金(QKH20167093); 贵州省科技厅自然科学基金(QKH Zhicheng [2017]2817); 贵州省科技厅自然科学基金(QKH Zhicheng [2018]2835)

收起

Synthesis of 2-Aryl Benzoxazoles from Benzoxazoles and α-Ketoic Acids by Photoredox Catalysis

  • Yadong Li ,
  • Pengju Wu ,
  • Zhiyong Yang
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  • Department of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003
*E-mail:

Received date: 2021-10-21

  Revised date: 2022-01-04

  Online published: 2022-02-25

Supported by

Scientific Research Foundation for Advanced Talents from Guizhou Institute of Technology(XJGC20180931); Science and Technology Foundation of Guizhou Province(QKHJZ20152060); Science and Technology Foundation of Guizhou Province(QKH20167093); Science and Technology Foundation of Guizhou Province(QKH Zhicheng [2017]2817); Science and Technology Foundation of Guizhou Province(QKH Zhicheng [2018]2835)

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摘要

发展了一种高效的可见光催化合成2-芳基苯并噁唑的方法. 与传统合成芳基苯并噁唑的方法相比, 该方法反应条件温和, 仅需要Eosin Y作为光催化剂, 不需要任何其他金属催化剂. 该反应副产物仅有CO2, 后处理简单. 在该反应条件下, 含有不同取代基的苯并噁唑与α-酮酸都呈现出非常好的反应活性, 能够合成一系列的芳基苯并噁唑.

关键词： 可见光催化; 2-芳基苯并噁唑; α-酮酸; 自由基反应

本文引用格式

李亚东 , 吴鹏举 , 杨志勇 . 可见光催化苯并噁唑与α-酮酸合成芳基苯并噁唑[J]. 有机化学, 2022 , 42(6) : 1770 -1777 . DOI: 10.6023/cjoc202110030

Abstract

An efficient protocol for the synthesis of 2-aryl benzoxazoles via visible light-initiation has been developed. Compared with the traditional method for the synthesis of arylbenzoxazole, the reaction conditions of this method are mild, and only Eosin Y is needed as photocatalyst without any other metal catalyst. The purification of the desired product is easier because only CO2 is produced as the byproduct. Under the optimal reaction conditions, benzoxazole with different substituents and α-keto acids show very good reactivity and a series of arylbenzoxazoles can be synthesized.

Key words： photoredox catalysis; 2-aryl benzoxazole; α-keto acid; radical reaction

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