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2022 , Vol. 42 >Issue 6: 1856 - 1862

DOI: https://doi.org/10.6023/cjoc202111006

研究简报

拟康定乌头中新的二萜生物碱及其拒食活性

  • 黄帅 ,
  • 冯宇明 ,
  • 任佳俐 ,
  • 杨传轮 ,
  • 陈琳 ,
  • 周先礼
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  • a 西南交通大学生命科学与工程学院 成都 610031
    b 西南交通大学宜宾研究院 四川宜宾 644000
    c 黄河三角洲京博化工研究院有限公司 山东滨州 256500

收稿日期: 2021-11-03

  修回日期: 2022-01-28

  网络出版日期: 2022-03-03

基金资助

国家自然科学基金(21807089); 四川省应用基础项目(2021YJ0222); 四川省应用基础项目(2020YJ0288); 中央高校基本科研业务费专项(2682021CX085); 教育部产学合作协同育人(202102414025); 教育部产学合作协同育人(202102414026)

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Diterpenoid Alkaloids from the Roots of Aconitum rockii and Their Antifeedant Activity

  • Shuai Huang ,
  • Yuming Feng ,
  • Jiali Ren ,
  • Chuanlun Yang ,
  • Lin Chen ,
  • Xianli Zhou
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  • a School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Yibin Institute of Southwest, Jiaotong University, Yibin, Sichuan 644000
    c Chambroad Chemical Industry Research Institute Co., Ltd, Binzhou, Shandong 256500
*E-mail: ;

Received date: 2021-11-03

  Revised date: 2022-01-28

  Online published: 2022-03-03

Supported by

National Natural Science Foundation of China(21807089); Science and Technology Support Programs of Sichuan Province(2021YJ0222); Science and Technology Support Programs of Sichuan Province(2020YJ0288); Fundamental Research Funds for Central Universities(2682021CX085); Industry-University Cooperation Collaborative Education Projects of Ministry of Education(202102414025); Industry-University Cooperation Collaborative Education Projects of Ministry of Education(202102414026)

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摘要

为了发现更多结构新颖活性优异的二萜生物碱, 继续对拟康定乌头化学成分进行研究, 从其乙醇提取物中分离得到4个新化合物, 通过HR-ESI-MS, 1D和2D NMR等波谱技术鉴定了结构, 分别为rockidines A~C (1~3)和rockisine A (4). 同时考察了化合物1~4及前期分离得到的二萜生物碱(5~14)对甜菜夜蛾3龄幼虫的拒食活性, 结果表明化合物13的拒食活性较好(EC50=0.13 mg/cm2).

关键词： 毛茛科; 拟康定乌头; 二萜生物碱; 拒食活性

本文引用格式

黄帅 , 冯宇明 , 任佳俐 , 杨传轮 , 陈琳 , 周先礼 . 拟康定乌头中新的二萜生物碱及其拒食活性[J]. 有机化学, 2022 , 42(6) : 1856 -1862 . DOI: 10.6023/cjoc202111006

Abstract

As part of our ongoing research program toward discovering structurally intriguing and biologically important diterpenoid alkaloids from the Aconitum genera, four new diterpenoid alkaloids, including three C19-diterpenoid alkaloids (rockidines A~C) and one C20-diterpenoid alkaloid (rockisine A) were isolated from the roots of Aconitum rockii Fletcher et Lauener in this paper. Their structures were elucidated on the basis of spectroscopic analyses (HR-ESI-MS, NMR and IR). All the new compounds 1~4, alone with ten known compounds 5~14 isolated in our previous work, were evaluated for their antifeedant activities, and compound 13 showed highly potent antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 0.13 mg/cm2.

Key words： Ranunculaceae; Aconitum rockii; diterpenoid alkaloids; antifeedant activity

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