布朗斯特酸催化合成亚砜亚胺基二氢吡喃酮类衍生物
收稿日期: 2021-08-12
修回日期: 2021-10-08
网络出版日期: 2022-02-24
基金资助
国家自然科学基金(21571027); 国家自然科学基金(21978039); 中央高校基本科研业务费(DUT20YG120)
Brønsted Acid-Catalyzed the Synthesis of Sulfoximide Substituted Dihydropyranone Derivatives
Received date: 2021-08-12
Revised date: 2021-10-08
Online published: 2022-02-24
Supported by
National Natural Science Foundation of China(21571027); National Natural Science Foundation of China(21978039); Fundamental Research Funds for the Central Universities(DUT20YG120)
孙鑫浩 , 段学伦 , 宋汪泽 , 姜文凤 . 布朗斯特酸催化合成亚砜亚胺基二氢吡喃酮类衍生物[J]. 有机化学, 2022 , 42(2) : 487 -497 . DOI: 10.6023/cjoc202108015
Both sulfoximide and dihydropyranone derivatives have potential bioactivities. However, it is still undisclosed to prepare sulfoximide-substituted dihydropyranone derivatives. Herein, diphenyl phosphate, as Brønsted acid was used to catalyze the nucleophilic substitution reactions of sulfoximides and dihydropyranones to afford sulfoximide substituted dihydropyranone derivatives in 44%~78% yields. This method features mild conditions, simple operation and good functional group compatibility, which avoids using noble metals in traditional manners and provides a novel and effective strategy for the synthesis of glycosides.
Key words： Brønsted acid; sulfoximidie; dihydropyranone; glycoside
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