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2022 , Vol. 42 >Issue 7: 2229 - 2235

DOI: https://doi.org/10.6023/cjoc202202007

研究论文

通过电化学Appel反应合成腈

  • 李海琼 ,
  • 尹梦云 ,
  • 谢芬芬 ,
  • 张正兵 ,
  • 韩盼 ,
  • 敬林海
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  • 西华师范大学化学化工学院 化学合成与污染控制四川省重点实验室 四川南充 637002
† 共同第一作者

收稿日期: 2022-02-06

  修回日期: 2022-03-11

  网络出版日期: 2022-03-22

基金资助

国家自然科学基金(22001217); 四川省科技厅(2021ZYD0064); 西华师范大学英才基金(17YC020); 西华师范大学基本科研业务费(19D037); 西华师范大学基本科研业务费(19E034)

收起

Synthesis of Nitrile via Electrochemical Appel Reaction

  • Haiqiong Li ,
  • Mengyun Yin ,
  • Fenfen Xie ,
  • Zhengbing Zhang ,
  • Pan Han ,
  • Linhai Jing
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  • Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, Sichuan 637002
† These authors contributed equally to this work
* E-mail: ;
* E-mail: ;

Received date: 2022-02-06

  Revised date: 2022-03-11

  Online published: 2022-03-22

Supported by

National Natural Science Foundation of China(22001217); Science and Technology Program of Sichuan Province(2021ZYD0064); Meritocracy Research Funds of China West Normal University(17YC020); Fundamental Research Funds of China West Normal University(19D037); Fundamental Research Funds of China West Normal University(19E034)

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摘要

探索了一种通过电化学Appel反应合成腈的方法. 该方法具有操作简单、反应条件温和、环境友好的优点, 可以合成一系列芳香腈和脂肪腈类化合物. 在循环伏安实验和控制实验基础上, 提出了电化学Appel反应机理用于解释反应过程.

关键词： 电化学合成; Appel反应; 肟的脱水; 腈的合成

本文引用格式

李海琼 , 尹梦云 , 谢芬芬 , 张正兵 , 韩盼 , 敬林海 . 通过电化学Appel反应合成腈[J]. 有机化学, 2022 , 42(7) : 2229 -2235 . DOI: 10.6023/cjoc202202007

Abstract

An electrochemical Appel reaction was developed for the synthesis of nitriles. This protocol features operationally simplicity, mild reaction conditions and environmental friendliness, enabling synthesis of various aromatic and aliphatic nitriles. Based on the controlled experiments and cyclic voltammetry (CV) experimental results, an electrochemical Appel reaction mechanism was proposed to explain the reaction process.

Key words： electrochemical synthesis; Appel reaction; dehydration of oximes; synthesis of nitriles

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