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2022 , Vol. 42 >Issue 7: 2243 - 2247

DOI: https://doi.org/10.6023/cjoc202112019

研究简报

栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

  • 刘绪 ,
  • 苏盼杰 ,
  • 崔文博 ,
  • 张宗萍 ,
  • 陈晓涵 ,
  • 王儒月 ,
  • 费冬青 ,
  • 张占欣
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  • 兰州大学药学院 功能有机分子化学国家重点实验室 兰州 730000
† 共同第一作者

收稿日期: 2021-12-15

  修回日期: 2022-03-23

  网络出版日期: 2022-03-30

基金资助

国家自然科学基金(31670350); 国家自然科学基金(31870324); 甘肃省自然科学基金(21JR7RA444); 甘肃省自然科学基金(21JR7RA477)

收起

A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

  • Xu Liu ,
  • Panjie Su ,
  • Wenbo Cui ,
  • Zongping Zhang ,
  • Xiaohan Chen ,
  • Ruyue Wang ,
  • Dongqing Fei ,
  • Zhanxin Zhang
Expand
  • School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000
† These authors contributed equally to this work.
* E-mail: ;

Received date: 2021-12-15

  Revised date: 2022-03-23

  Online published: 2022-03-30

Supported by

National Natural Science Foundation of China(31670350); National Natural Science Foundation of China(31870324); Natural Science Foundation of Gansu Province(21JR7RA444); Natural Science Foundation of Gansu Province(21JR7RA477)

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摘要

从栗色鼠尾草全草的乙醇提取物中分离得到一个新的吉马烷型倍半萜内酯类化合物salviatanolide A (1). 化合物1的结构通过一维/二维NMR和HRESIMS波谱分析技术得到确认. 通过X-ray单晶衍射实验还确认了化合物1的绝对构型. 利用人源化秀丽隐杆线虫的阿尔兹海默症病理模型, 筛选了化合物1的抗阿尔兹海默症活性. 生物活性结果表明, 化合物1能显著地延缓秀丽隐杆线虫麻痹表型的阿尔兹海默症症状, 提示该化合物可作为抗阿尔兹海默症的候选化合物.

关键词： 栗色鼠尾草; 吉马烷型倍半萜内酯; 抗阿尔兹海默症活性; 秀丽隐杆线虫

本文引用格式

刘绪 , 苏盼杰 , 崔文博 , 张宗萍 , 陈晓涵 , 王儒月 , 费冬青 , 张占欣 . 栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物[J]. 有机化学, 2022 , 42(7) : 2243 -2247 . DOI: 10.6023/cjoc202112019

Abstract

One new germacrane-type sesquiterpene lactone, named as salviatanolide A (1) was isolated from an ethanol extract of the whole plant of Salvia castanea. Its structure was elucidated by 1D and 2D-NMR and HRESIMS spectra, and its absolute configuration was determined by single crystal X-ray crystallography. The anti-Alzheimer’s disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model. Compound 1 significantly delayed AD-like symptoms of worm paralysis phenotype, which may be potential to be served as anti-AD agent candidate.

Key words： Salvia castanea; germacrane-type sesquiterpene lactone; anti-Alzheimer’s disease activity; Caenorhabditis elegans

参考文献

[1]
Pan, Z. H.; Li, Y.; Wu, X. D.; He, J.; Chen, X. Q.; Xu, G.; Peng, L. Y.; Zhao, Q. S. Fitoterapia 2012, 83, 1072.
[2]
Editorial Committee of Flora of China Flora of China, Vol. 66, Science Press, Beijing, 1977, pp. 70-71. (in Chinese)
[2]
( 中国科学院中国植物志编辑委员会, 中国植物志,第66卷,科学出版社,北京, 1977, pp. 70-71).
[3]
Pan, Z. H.; He, J. A.; Li, Y; Zhao, Y.; Wu, X. D.; Wang, K.; Peng, L. Y.; Xu, G.; Zhao, Q. S. Tetrahedron Lett. 2010, 51, 5083.
[4]
Xia, G. H.; Li, Y. P.; Bi, D. W.; Zhang, L. J.; Li, H. Z.; Gao, L. H.; Wang, L. Q. Chin. J. Org. Chem. 2017, 37, 2772. (in Chinese)
[4]
( 夏光惠, 李元平, 毕德文, 张兰军, 李宏哲, 高林花, 王利勤, 有机化学, 2017, 37, 2772.)
[5]
Ulubelen, A.; Birman, H.; Oksuz, S.; Topcu, G.; Kolak, U.; Barla, A.; Voelter, W. Planta Med. 2002, 68, 818.
[6]
Ulubelen, A. Phytochemistry 2003, 64, 395.
[7]
Halfon, B.; Cetin, O.; Kokdil, G.; Topcu, G. Rec. Nat. Prod. 2019, 13, 156.
[8]
Wang, X. H.; Bastow, K. F.; Sun, C. M.; Lin, Y. L.; Yu, H. J.; Don, M. J.; Wu, T. S.; Nakamura, S.; Lee, K. H. J. Med. Chem. 2004, 47, 5816.
[9]
Huang, M. Q.; Xie, Y. L.; Chen, L. D.; Chu, K. D.; Wu, S. S.; Lu, J. J.; Chen, X. P.; Wang, Y. T.; Lai, X. P. Phytother. Res. 2012, 26, 944.
[10]
Li, L. N.; Wei, S. S.; Zhu, T. Y.; Xue, G. M.; Xu, D. Q.; Wang, W. L.; Wang, X. B.; Luo, J. G.; Kong, L. Y. J. Funct. Foods 2019, 54, 154.
[11]
Wu, Y. B.; Ni, Z. Y.; Shi, Q. W.; Dong, M.; Kiyota, H.; Gu, Y. C.; Cong, B. Chem. Rev. 2012, 112, 5967.
[12]
Zheng, X. F.; Kadir, A.; Zheng, G. J.; Jin, P. F.; Qin, D. M.; Maiwulanjiang, M.; Aisa, H. A.; Yao, G. M. Bioorg. Chem. 2020, 104, 104261.
[13]
Xu, J. P.; Wei, K. H.; Zhang, G. J.; Lei, L. J.; Yang, D. W.; Wang, W. L.; Han, Q. H.; Xia, Y.; Bi, Y. Q.; Yang, M.; Li, M. H. J. Ethnopharmacol. 2018, 225, 18.
[14]
Peng, Q.; Liu, J. X. Chin. J. Chin. Mater. Med. 2015, 40, 2096. (in Chinese)
[14]
( 彭勍, 刘建勋, 中国中药杂志, 2017, 40, 2096.)
[15]
Editorial Committee of Flora of China Flora of China, Vol. 66, Science Press, Beijing, 1977, pp. 124-126. (in Chinese)
[15]
( 中国科学院中国植物志编辑委员会, 中国植物志, 第66卷, 科学出版社, 北京, 1977, pp. 124-126.)
[16]
Su, P. J.; Zhang, Z. P.; Cui, W. B.; Liu, X.; Wang, R. Y.; Zhi, D. J.; Qi, F. M.; Chen, X. H.; Li, Y. Q.; Djimabi, K.; Guo, Y. Q.; Zhang, Z. X.; Fei, D. Q. Fitoterapia 2021, 151, 104867.
[17]
Ali, M. S.; Ibrahim, S. A.; Ahmed, S.; Lobkovsky, E. Z. Naturforsch., B: Chem. Sci. 2007, 62, 1333.
[18]
Scholtzova, H.; Wadghiri, Y. Z.; Douadi, M.; Sigurdsson, E. M.; Li, Y. S.; Quartermain, D.; Banerjee, P.; Wisniewski, T. J. Neurosci. Res. 2008, 86, 2784.
[19]
Xin, L. J.; Yamujala, R.; Wang, Y. H.; Wang, H.; Wu, W. H.; Lawton, M. A.; Long, C. L.; Di, R. PLoS One 2013, 8, e63874.
[20]
Xie, H. G.; Chen, H.; Cao, B.; Zhang, H. W.; Zou, Z. M. Chem. Pharm. Bull. 2007, 55, 1258.
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