高效合成含P—O—P键化合物: 焦膦酸酯、四烷基焦膦酸酯和焦膦酰胺的方法
收稿日期: 2022-02-07
修回日期: 2022-03-05
网络出版日期: 2022-03-30
基金资助
国民核生化灾害防护国家重点实验室(SKLNBC2021-09)
Development of an Efficient Method for the Synthesis of Compounds Containing P—O—P Bonds: Pyrophosphonates, Tetraalkyl Pyrophosphates and Pyrophosphonamidates
Received date: 2022-02-07
Revised date: 2022-03-05
Online published: 2022-03-30
Supported by
State Key Laboratory of Nuclear Biological and Chemical Protection for Civilian(SKLNBC2021-09)
张子璇 , 高润利 , 胡慧娟 , 卢晓刚 , 王瑾陈霄 , 王红梅 . 高效合成含P—O—P键化合物: 焦膦酸酯、四烷基焦膦酸酯和焦膦酰胺的方法[J]. 有机化学, 2022 , 42(7) : 2214 -2221 . DOI: 10.6023/cjoc202201050
This work describes a method of synthesizing pyrophosphonates, tetraalkyl pyrophosphates and pyrophosphonamidates. Pyrophosphonates can be synthesized by the reaction of alkyl dichlorophosphonate, triethylamine (Et3N), and water, in a molar ratio of 1∶1.2∶0.5 (dichlorophosphonate∶Et3N∶water). When the reaction was allowed to proceed for 15 min in acetone, the maximum yield recorded for the pyrophosphonates was 95%. Et3N was the solvent, with an acid-binding agent. Following this method, the achieved rate of production of tetraalkyl pyrophosphate and pyrophosphonamidate was faster than the rate of production of the compounds reached using traditional methods.
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