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2022 , Vol. 42 >Issue 3: 901 - 904

DOI: https://doi.org/10.6023/cjoc202109024

研究简报

海绵Spongia sp.中一个新的D环为吡啶环的降海绵烷型二萜

  • 梁咏倩 ,
  • 廖小建 ,
  • 凌珑 ,
  • 杨雅婷 ,
  • 赵冰心 ,
  • 徐石海
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  • a 暨南大学化学与材料学院 广州 510632
    b 广东药科大学药学院 广州 510006
† 共同第一作者

收稿日期: 2021-09-22

  修回日期: 2021-10-19

  网络出版日期: 2021-11-09

基金资助

国家重点研发计划(2019YFD0901905); 国家重点研发计划(2018YFC0310900); 国家自然科学基金(41876145); 国家自然科学基金(81874292); 国家自然科学基金(21672084); 广州市科技计划(202102010066); 广州市科技计划(201704030042)

收起

A New Dinorspongian Diterpene with Pyridyl D-Ring from the Marine Sponge Spongia sp.

  • Yongqian Liang ,
  • Xiaojian Liao ,
  • Long Ling ,
  • Yating Yang ,
  • Bingxin Zhao ,
  • Shihai Xu
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  • a College of Chemistry and Materials Science, Jinan University, Guangzhou 510632
    b College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006
† These authors contributed equally to this work.
* Corresponding authors. E-mail: ;

Received date: 2021-09-22

  Revised date: 2021-10-19

  Online published: 2021-11-09

Supported by

National Key Research and Development Plan of China(2019YFD0901905); National Key Research and Development Plan of China(2018YFC0310900); National Natural Science Foundation of China(41876145); National Natural Science Foundation of China(81874292); National Natural Science Foundation of China(21672084); Science and Technology Planning Project of Guangzhou(202102010066); Science and Technology Planning Project of Guangzhou(201704030042)

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摘要

在对一种Spongia属海绵的化学成分研究中, 分离得到一个新的降海绵烷型二萜dinorspongiapyridine (1)和四个已知化合物2~5. 通过核磁共振波谱、单晶X-ray衍射以及对比文献的方法, 确定了这些化合物的结构及其绝对构型. 化合物1是首次发现的D环为吡啶环的3,4-裂环-3,19-双降海绵烷型二萜类化合物, 并对其细胞毒活性进行了测试. 此外, 对化合物1的生物合成途径也进行了探讨.

关键词： 海绵; Spongia; 降海绵烷型二萜; 吡啶环

本文引用格式

梁咏倩 , 廖小建 , 凌珑 , 杨雅婷 , 赵冰心 , 徐石海 . 海绵Spongia sp.中一个新的D环为吡啶环的降海绵烷型二萜[J]. 有机化学, 2022 , 42(3) : 901 -904 . DOI: 10.6023/cjoc202109024

Abstract

Chemical investigation of the marine sponge Spongia sp. led to a new dinorspongian diterpene dinorspongiapyridine (1) together with four known compounds 2~5. Compound 1 was the first instance of 3,4-seco-3,19-dinorspongian diterpene bearing a rare pyridyl D-ring system. The structure with absolute configuration of 1 was elucidated by the methods of NMR and X-ray diffraction. In addition, the cytotoxic activities against several cancer cell lines of 1 were evaluated. The plausible biogenetic pathway of 1 was also proposed.

Key words： sponge; Spongia; dinorspongian diterpene; pyridyl ring

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