多孔有机膦配体聚合物作为可回收配体用于异吲哚啉酮类化合物的合成
收稿日期: 2022-01-25
修回日期: 2022-03-17
网络出版日期: 2022-04-15
基金资助
广西重点研发计划(AB18221005); 国家自然科学基金(22061003); 国家自然科学基金(22161008); 广西省自然科学基金(2021GXNSFFA220005); 广西省自然科学基金(RZ1900005748); 广西省自然科学基金(2021GXNSFBA196041)
Porous Organophosphine Ligand Polymers as Recyclable Ligands for the Synthesis of Isoindolinone Compounds
Received date: 2022-01-25
Revised date: 2022-03-17
Online published: 2022-04-15
Supported by
Guangxi Key R&D Program(AB18221005); National Natural Science Foundation of China(22061003); National Natural Science Foundation of China(22161008); Natural Science Foundation of Guangxi Province(2021GXNSFFA220005); Natural Science Foundation of Guangxi Province(RZ1900005748); Natural Science Foundation of Guangxi Province(2021GXNSFBA196041)
报道了金属钯/多孔有机膦配体(Pd/POL-PPh3)在非均相条件下用于高效合成异吲哚啉酮类化合物. 与均相条件相比, 该方法具有更高的产率. 同时POL-PPh3可以循环使用, 降低了反应的成本. 该反应中, POL-PPh3具有多孔结构, 且反应前后的形貌没有发生明显变化, 其独特的稳定性是POL-PPh3作为多相配体具有高活性以及可回收的根本原因.
关键词： 异吲哚啉酮; 金属钯/多孔有机磷配体; 可重复使用; 高稳定性
庞丽萍 , 杨昌杰 , 林洪敏 , 李心宇 , 唐海涛 , 潘英明 . 多孔有机膦配体聚合物作为可回收配体用于异吲哚啉酮类化合物的合成[J]. 有机化学, 2022 , 42(7) : 2117 -2123 . DOI: 10.6023/cjoc202201043
Isoindolinone compounds were efficiently synthesized with Pd-metalated/porous organophosphorus ligand (Pd/ POL-PPh3) under heterogeneous conditions. Compared with homogeneous conditions, this method has higher yield, at the same time, the POL-PPh3 can be recycled, which reduces the cost of the reaction. In this reaction, POL-PPh3 has porous structure without obvious change during the reaction progress of the morphology, and this unique stability is the fundamental reason for the high activity and recyclability of POL-PPh3 as heterogeneous ligand.
Key words： isoindolinone; Pd/POLs; recyclable; high stability
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