基于莪术醇胺氟化结构修饰的三维天然产物片段库的构建
收稿日期: 2022-02-06
修回日期: 2022-03-26
网络出版日期: 2022-04-15
基金资助
国家自然科学基金(22001096); 国家自然科学基金(21871086); 浙江省自然科学基金(LQ21B020008); 嘉兴学院启动经费(CD70519040); 嘉兴学院“百青”培养人才(CD70621018)
Aminofluorination-Based Structural Modification of Curcumol for the Construction of 3D-Shaped Natural Product Fragment Library
Received date: 2022-02-06
Revised date: 2022-03-26
Online published: 2022-04-15
Supported by
National Natural Science Foundation of China(22001096); National Natural Science Foundation of China(21871086); Natural Science Foundation of Zhejiang Province(LQ21B020008); Start Up Funds of Jiaxing University(CD70519040); Jiaxing University "Hundred Youth" Training Talents(CD70621018)
李响 , 张依凡 , 陆凯琳 , 刘石惠 , 张永强 . 基于莪术醇胺氟化结构修饰的三维天然产物片段库的构建[J]. 有机化学, 2022 , 42(7) : 2124 -2133 . DOI: 10.6023/cjoc202202006
The biological significance of sp3-rich synthetic scaffolds with natural product like features yet distinct global frameworks is being increasingly recognized in medicinal chemistry and biochemistry. Herein, a fragment library consisting of 3D-shaped natural product fragments was assembled. Library construction was performed by photocatalytic amidofluorination of curcumol to incorporate amine and fluorine as potential binding groups and synthetic growth points. Through this strategy, a fragment library of 24 fragments was generated, which was demonstrate to have high three-dimensionality, natural product likeness and superior fragment-like properties, covering a novel chemical space in fragment based drug discovery.
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