镍催化炔烃的立体选择性芳基-二氟烷基化反应
Nickel-Catalyzed Stereoselective Aryl-Difluoroalkylation of Alkynes
Received date: 2022-03-28
Revised date: 2022-04-24
Online published: 2022-05-07
孙奇 , 孙泽颖 , 俞泽 , 王光伟 . 镍催化炔烃的立体选择性芳基-二氟烷基化反应[J]. 有机化学, 2022 , 42(8) : 2515 -2520 . DOI: 10.6023/cjoc202203054
A nickel-catalyzed aryl-difluoroalkylation of alkynes is developed. A series of trisubstituted fluoroalkenes can be obtained in a highly stereoselective manner by mixing of simple starting materials alkynes, ethyl bromodifluoroacetate, and arylboronic acids in the presence of nickel catalyst. This method features low-cost catalyst, mild reaction conditions, and excellent functional group compatibility.
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