三氟甲磺酸酐介导炔酰胺与吡啶加成反应的研究
收稿日期: 2022-03-31
修回日期: 2022-04-29
网络出版日期: 2022-05-27
基金资助
国家自然科学基金(21772027)
Trifluoromethyl Sulfonic Anhydride Mediated Addition of Pyridine with Ynamides
Received date: 2022-03-31
Revised date: 2022-04-29
Online published: 2022-05-27
Supported by
National Natural Science Foundation of China(21772027)
宋昊儒 , 孙建婷 , 吕敏 , 刘艺雯 , 魏邦国 . 三氟甲磺酸酐介导炔酰胺与吡啶加成反应的研究[J]. 有机化学, 2022 , 42(8) : 2433 -2437 . DOI: 10.6023/cjoc202203061
A convenient approach to pyridine quaternary ammonium salts containing enamine fragment has been developed, which features a trifluoromethyl sulfonic anhydride mediated regioselective addition process of pyridine with ynamides. Using this method, a variety of substituted pyridine quaternary ammonium salts containing enamine fragment 3a~3m were prepared in moderate to excellent yields with high regioselectivities (Z:E up to 20:1).
Key words： ynamides; pyridine; addition reaction; pyridine quaternary ammonium salt
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