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2022 , Vol. 42 >Issue 9: 2682 - 2702

DOI: https://doi.org/10.6023/cjoc202204056

综述与进展

过渡金属催化N-芳基酞嗪的C—H键活化反应研究进展

  • 顾海春 ,
  • 靳新新 ,
  • 李嘉琪 ,
  • 李贺 ,
  • 刘景林
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  • a 内蒙古民族大学化学与材料学院 内蒙古通辽 028000
    b 内蒙古自治区天然产物化学及功能分子合成重点实验室 内蒙古通辽 028000

收稿日期: 2022-04-22

  修回日期: 2022-06-01

  网络出版日期: 2022-06-17

基金资助

内蒙古自然科学基金(2020BS02014); 内蒙古民族大学博士科研启动基金(BS560)

收起

Recent Progress in Transition Metal-Catalyzed C—H Bond Activation of N-Aryl Phthalazinones

  • Haichun Gu ,
  • Xinxin Jin ,
  • Jiaqi Li ,
  • He Li ,
  • Jinglin Liu
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  • a College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000
    b Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, Tongliao, Inner Mongolia 028000
* Corresponding authors. E-mail: ;

Received date: 2022-04-22

  Revised date: 2022-06-01

  Online published: 2022-06-17

Supported by

Inner Mongolia Natural Science Foundation(2020BS02014); Inner Mongolia Minzu University Doctoral Research Startup Fund Project(BS560)

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摘要

N-芳基酞嗪是存在于天然产物及药物分子中的一种重要含氮芳香杂环化合物, 同时, 也是非常重要的有机合成原料. 近年来, 随着过渡金属催化C—H键活化研究的发展, 通过切断酞嗪衍生物的C—H键来实现制备含氮杂环化合物, 吸引了越来越多化学家们的关注. 通过对不同偶联组分的分类, 综述了近年来酞嗪参与的过渡金属催化C—H键活化反应最新研究进展, 并对反应机理进行了论述.

关键词： N-芳基酞嗪; 过渡金属; C—H键活化; 偶联组分

本文引用格式

顾海春 , 靳新新 , 李嘉琪 , 李贺 , 刘景林 . 过渡金属催化N-芳基酞嗪的C—H键活化反应研究进展[J]. 有机化学, 2022 , 42(9) : 2682 -2702 . DOI: 10.6023/cjoc202204056

Abstract

N-Aryl phthalazinones are important nitrogen heterocycles widely existing in the natural products and drug molecules. Meanwhile, N-aryl phthalazinones are also very significant substrates for organic synthesis. In recent years, with the development of C—H bond activation catalyzed by transition metal, the synthesis of nitrogen heterocycles via the C—H bond cleavage of phthalazines derivatives has attracted attention of chemists. In this paper, the recent progress of the transition metal-catalyzed C—H bond activation reaction of phthalazines is reviewed by classifying different coupling components, and the reaction mechanism is discussed.

Key words： N-aryl phthalazinones; transition metal; C—H bond activation; coupling partners

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