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2022 , Vol. 42 >Issue 9: 2961 - 2966

DOI: https://doi.org/10.6023/cjoc202202016

研究简报

蓝花黄芩内生真菌Aspergillus terreus HQ100X-1次级代谢产物研究

  • 黄丹 ,
  • 农旭华 ,
  • 杨建妮 ,
  • 李琛 ,
  • 韩长日 ,
  • 陈光英 ,
  • 宋小平 ,
  • 孙振范 ,
  • 惠阳 ,
  • 陈文豪
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  • a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158
    c 海南科技职业大学 药食同源植物资源海南省重点实验室 海口 571126
† 共同第一作者

收稿日期: 2022-02-13

  修回日期: 2022-03-28

  网络出版日期: 2022-06-23

基金资助

国家自然科学基金(22167013); 海南省重点研发项目(ZDYF2021SHFZ221); 海南省自然科学基金(221RC541); 海南省教育厅项目(Hnky2021ZD-10); 海南省研究生创新科研课题(Hys2021-72); 大学生创新创业训练计划(202111658002); 大学生创新创业训练计划(202111658003)

收起

Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

  • Dan Huang ,
  • Xuhua Nong ,
  • Jianni Yang ,
  • Chen Li ,
  • Changri Han ,
  • Guangying Chen ,
  • Xiaoping Song ,
  • Zhenfan Sun ,
  • Yang Hui ,
  • Wenhao Chen
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    c Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126
† These authors contributed equally to this work
* Corresponding authors. E-mail: ;
;

Received date: 2022-02-13

  Revised date: 2022-03-28

  Online published: 2022-06-23

Supported by

National Natural Science Foundation of China(22167013); Key Project of Research and Development of Hainan Province(ZDYF2021SHFZ221); Hainan Provincial Natural Science Foundation of China(221RC541); Education Department of Hainan Province(Hnky2021ZD-10); Program for Hainan Provincial Graduate Innovation Research Project(Hys2021-72); Innovation Training Program for College Students(202111658002); Innovation Training Program for College Students(202111658003)

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摘要

从蓝花黄芩内生真菌土曲霉(Aspergillus terreus) HQ100X-1发酵产物中分离得到2个新化合物[terrustone (1)和asperteretone G (2)], 10个已知化合物(3~12), terrustone (1)为具有4个连续手性中心的三羟基环戊酮类化合物, 它们的结构以及绝对构型是通过1D/2D NMR结合电子圆二色谱(ECD)计算来确定. 抗菌实验表明, 化合物rbrolide R (4)对金黄色葡萄球菌有一定的抑菌活性, 其最低抑菌浓度(MIC)值为2.5 μg/mL.

关键词： 蓝花黄芩; 土曲霉(Aspergillus terreus); 抗菌活性

本文引用格式

黄丹 , 农旭华 , 杨建妮 , 李琛 , 韩长日 , 陈光英 , 宋小平 , 孙振范 , 惠阳 , 陈文豪 . 蓝花黄芩内生真菌Aspergillus terreus HQ100X-1次级代谢产物研究[J]. 有机化学, 2022 , 42(9) : 2961 -2966 . DOI: 10.6023/cjoc202202016

Abstract

Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 μg/mL.

Key words： scutellaria formosana; Aspergillus terreus; antibacterial activity

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