I2催化下通过2-氨基吡啶和N-对甲苯磺酰腙氧化偶联反应合成1,2,4-三唑[4,3-a]吡啶
收稿日期: 2022-05-23
修回日期: 2022-06-24
网络出版日期: 2022-07-05
基金资助
国家自然科学基金(42002174); 甘肃省自然科学基金(20JR10RA030); 宁夏重点研发(2019BEB04028)
Synthesis of 1,2,4-Triazolo[4,3-a]pyridines by I2-Catalyzed Oxidative Coupling of 2-Aminopyridines with N-Tosylhydrazones
Received date: 2022-05-23
Revised date: 2022-06-24
Online published: 2022-07-05
Supported by
National Natural Science Foundation of China(42002174); Natural Science Foundation of Gansu Province(20JR10RA030); Ningxia Key Research and Development Program(2019BEB04028)
报道了一种利用N-对甲苯磺酰腙和2-氨基吡啶为原料, 通过S—N/C—N键裂解和新的C—N键形成, 高效合成1,2,4-三唑[4,3-a]吡啶类化合物的新路线. 该方法以I2为催化剂, 是一种简单、通用且高效的方法, 适应于不同取代基的各类底物, 并能以较好的产率得到目标化合物.
关键词： 过氧化氢叔丁醇; 2-氨基吡啶; N-对甲苯磺酰腙; 环化; 1,2,4-三唑[4,3-a]吡啶
陈永欣 , 郭鑫 , 刘亚凤 , 杨雪莹 , 陈保华 . I2催化下通过2-氨基吡啶和N-对甲苯磺酰腙氧化偶联反应合成1,2,4-三唑[4,3-a]吡啶[J]. 有机化学, 2022 , 42(11) : 3863 -3869 . DOI: 10.6023/cjoc202205040
An efficient synthesis of 1,2,4-triazolo[4,3-a]pyridines from N-tosylhydrazones and 2-aminopyridines via S—N/ C—N bond cleavage and new C—N bond formation has been developed. The procedure, using I2 as the catalyst, is a simple, general, and efficient protocol, which could be applied to various substrates in moderate to good yields.
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