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2023 , Vol. 43 >Issue 2: 712 - 717

DOI: https://doi.org/10.6023/cjoc202206007

研究论文

一种裸眼和荧光双通道快速检测Hg2+的探针及其多种应用

  • 唐宏伟 ,
  • 王超 ,
  • 钟克利 ,
  • 侯淑华 ,
  • 汤立军 ,
  • 边延江
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  • 渤海大学化学与材料工程学院 辽宁锦州 121000

收稿日期: 2022-06-06

  修回日期: 2022-08-29

  网络出版日期: 2022-10-10

基金资助

国家自然科学基金(22278038); 辽宁特聘教授支持计划资助项目.

收起

A Naked-Eye and Fluorescent Dual-Channel Probe for Rapid Detection of Hg2+ and Its Multiple Applications

  • Hongwei Tang ,
  • Chao Wang ,
  • Keli Zhong ,
  • Shuhua Hou ,
  • Lijun Tang ,
  • Yanjiang Bian
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  • College of Chemistry and Material Engineering, Bohai University, Jinzhou, Liaoning 121000
* Corresponding authors. E-mail: ;

Received date: 2022-06-06

  Revised date: 2022-08-29

  Online published: 2022-10-10

Supported by

National Natural Science Foundation of China(22278038); Program for Distinguished Professor of Liaoning Province.

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摘要

设计并合成了一种在二甲基亚砜(DMSO)/磷酸缓冲溶液(PBS) (V∶V=5∶5, pH=10.17)中识别Hg2+的荧光探针HMI-Hg2+. HMI-Hg2+通过荧光信号增强识别Hg2+, 并且溶液颜色在几秒钟内发生改变. 光谱实验证实了该探针对 Hg2+具有高选择性和高灵敏度, 检测限为0.22 μmol/L. HMI-Hg2+在水样和海鲜样品(鱼、虾和扇贝)中具有出色的检测效果. 此外, HMI-Hg2+可用于在MCF-7细胞中对Hg2+进行成像, 并具有线粒体靶向能力.

关键词： 荧光探针; Hg2+; 海鲜样品; 细胞成像

本文引用格式

唐宏伟 , 王超 , 钟克利 , 侯淑华 , 汤立军 , 边延江 . 一种裸眼和荧光双通道快速检测Hg2+的探针及其多种应用[J]. 有机化学, 2023 , 43(2) : 712 -717 . DOI: 10.6023/cjoc202206007

Abstract

A fluorescent probe HMI-Hg2+ was designed and synthesized to recognize Hg2+ in dimethyl sulfoxide (DMSO)/ phosphate buffer solution (PBS) (V∶V=5∶5, pH=10.17). HMI-Hg2+ recognized Hg2+ through the fluorescence signal strengthen, and solution color shifted within a few seconds. Spectral experiments confirmed the advantages of the probe with high selectivity and sensitivity to Hg2+. The detection limit was calculated to be 0.22 μmol/L. HMI-Hg2+ has excellent detection consequences in water samples and seafood samples (fish, shrimp and scallop). Moreover, HMI-Hg2+ can be applied for the cell imaging of Hg2+ in MCF-7 and has mitochondria-targeted capabilities.

Key words： fluorescent probe; Hg2+; seafood sample; cell imaging

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