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2023 , Vol. 43 >Issue 2: 771 - 776

DOI: https://doi.org/10.6023/cjoc202207005

研究简报

牛筋果茎中一个新的异戊烯基异黄酮类化合物

  • 沈章阳 ,
  • 李玉洁 ,
  • 赵艺萌 ,
  • 邓雅源 ,
  • 郭亚文 ,
  • 王俞 ,
  • 刘艳萍 ,
  • 付艳辉
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  • a 海南师范大学 热带药用资源化学教育部重点实验室 海口 571127
    b 海南师范大学 南药资源产业化关键技术研究海南省工程研究中心 海口 571127
    c 海南师范大学 海口市热带果蔬研究与开发重点实验室 海口 571127
†共同第一作者

收稿日期: 2022-07-04

  修回日期: 2022-08-09

  网络出版日期: 2022-10-10

基金资助

海南省重点研发计划(ZDYF2022SHFZ028); 国家自然科学基金(22067005); 国家自然科学基金(32070390); 国家自然科学基金(21967008); 海南省自然科学基金(222RC655); 海南省自然科学基金(2019RC198); 海南省自然科学基金(220RC596); 海口市重点研发计划(2017050); 海口市重点研发计划(2020054)

收起

A New Prenylated Isoflavone from the Stems of Harrisonia perforata

  • Zhangyang Shen ,
  • Yujie Li ,
  • Yimeng Zhao ,
  • Yayuan Deng ,
  • Yawen Guo ,
  • Yu Wang ,
  • Yanping Liu ,
  • Yanhui Fu
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571127
    b Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University, Haikou 571127
    c Key Laboratory of Research and Development of Tropical Fruits and Vegetables of Haikou City, Hainan Normal University, Haikou 571127
†(The authors contributed equally to this work).
* Corresponding authors. E-mail: ;

Received date: 2022-07-04

  Revised date: 2022-08-09

  Online published: 2022-10-10

Supported by

Key Research and Development Project of Hainan Province(ZDYF2022SHFZ028); National Natural Science Foundation of China(22067005); National Natural Science Foundation of China(32070390); National Natural Science Foundation of China(21967008); National Natural Science Foundation of Hainan Province(222RC655); National Natural Science Foundation of Hainan Province(2019RC198); National Natural Science Foundation of Hainan Province(220RC596); Key Research and Development Project of Haikou City(2017050); Key Research and Development Project of Haikou City(2020054)

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摘要

综合运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱(HPLC)等色谱分离手段, 对苦木科牛筋果属植物牛筋果Harrisonia perforata茎中的化学成分进行了研究, 从其茎的95%乙醇提取物中分离得到了8个异戊烯基异黄酮类化合物, 采用多种波谱鉴定方法确定了这些分离得到化合物的化学结构, 其中化合物1为1个新的异戊烯基异黄酮类化合物, 化合物2~8为从牛筋果属植物中分离得到的化合物. 化合物1~8体外抑制肿瘤细胞生长的活性评价结果表明, 它们对五种肿瘤细胞株(HL-60、A549、SMMC-7721、MCF-7和SW480)均具有较为显著的体外生长抑制活性, 抑制肿瘤细胞生长的活性的IC50范围为(0.38±0.03)~(31.68±0.21) μmol/L, 抑制肿瘤细胞生长的活性与抗肿瘤阳性对照药顺铂的抑制活性相当.

关键词： 牛筋果属; 牛筋果; 异戊烯基异黄酮; 抑制肿瘤细胞生长活性

本文引用格式

沈章阳 , 李玉洁 , 赵艺萌 , 邓雅源 , 郭亚文 , 王俞 , 刘艳萍 , 付艳辉 . 牛筋果茎中一个新的异戊烯基异黄酮类化合物[J]. 有机化学, 2023 , 43(2) : 771 -776 . DOI: 10.6023/cjoc202207005

Abstract

A new prenylated isoflavone, harriperforine (1), as well as seven known analogues, was isolated and characterized from the stems of Harrisonia perforata. Their chemical structures were unambiguously elucidated based on spectroscopic analyses. All known compounds 2~8 were isolated from the genus Harrisonia for the first time. The growth inhibitory activities against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480) of compounds 1~8 were evaluated. As a result, compounds 1~8 displayed remarkable inhibitory activities with IC50 values ranging from (0.38±0.03) μmol/L to (31.68±0.21) μmol/L, which were comparable to those of cisplatin.

Key words： Harrisonia; H. perforata; prenylated isoflavone; tumor cell growth inhibitory activities

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