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2022 , Vol. 42 >Issue 10: 3129 - 3142

DOI: https://doi.org/10.6023/cjoc202208024

综述与进展

手性膦催化的氮杂环合成研究进展

  • 任红霞 ,
  • 马萌萌 ,
  • 黄有
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  • 南开大学化学学院 元素有机化学国家重点实验室 天津 300071

收稿日期: 2022-08-19

  修回日期: 2022-10-11

  网络出版日期: 2022-10-14

基金资助

国家自然科学基金(22171147); 国家自然科学基金(21871148); 国家自然科学基金(21672109)

收起

Progress in Synthesis of Nitrogen Heterocycles Catalyzed by Chiral Phosphine

  • Hongxia Ren ,
  • Mengmeng Ma ,
  • You Huang
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  • State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
Dedicated to the 60th anniversary of Institute of Elemento-Organic Chemistry at Nankai University.
* Corresponding author. E-mail:

Received date: 2022-08-19

  Revised date: 2022-10-11

  Online published: 2022-10-14

Supported by

National Natural Science Foundation of China(22171147); National Natural Science Foundation of China(21871148); National Natural Science Foundation of China(21672109)

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摘要

手性氮杂环是一类重要的有机分子, 这类骨架广泛存在于药物、农药以及许多具有生物活性的天然产物分子中, 手性含氮杂环的合成是有机合成化学中的重要研究领域, 有机催化反应是合成氮杂环的重要方法, 在这些方法中, 手性有机膦催化的氮杂环的合成被证明是一个实用且强大的方法. 对近年来手性膦催化的氮杂环的合成反应进行了综述, 并对该领域的发展方向进行了展望.

关键词： 手性膦催化剂; 有机催化; 环化反应; 手性氮杂环

本文引用格式

任红霞 , 马萌萌 , 黄有 . 手性膦催化的氮杂环合成研究进展[J]. 有机化学, 2022 , 42(10) : 3129 -3142 . DOI: 10.6023/cjoc202208024

Abstract

Chiral aza-heterocycles are important molecular skeletons of organic chemistry, which are extensively found in pharmaceuticals, pesticides and biologically active natural products. As a significant organic chemistry research filed, the development of efficient novel synthetic methods of them has been a challenge. Among these strategies for the synthesis of aza-heterocycles compounds, chiral phosphine organocatalysis provides a practical and powerful platform. The recent progress in synthesis of chiral nitrogen heterocycles catalyzed by chiral phosphine is summarized, and the development of this field is also prospected.

Key words： chiral phosphine catalyst; organocatalysis; annulation reaction; chiral N-heterocycle

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