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2023 , Vol. 43 >Issue 2: 751 - 755

DOI: https://doi.org/10.6023/cjoc202208019

研究简报

长叶暗罗中克罗烷型二萜及其抗炎作用

  • 余章昕 ,
  • 宋鑫明 ,
  • 姚远 ,
  • 杨俊 ,
  • 杨硕 ,
  • 李小宝
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  • a 海南师范大学 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158

收稿日期: 2022-08-15

  修回日期: 2022-10-05

  网络出版日期: 2022-11-01

基金资助

海南省自然科学基金(221MS034); 海南省自然科学基金(220MS036); 海南省重点研发(ZDYF2022SHFZ286); 海南省重点研发(ZDYF2021SHFZ072); 海南省教育厅(Hnky 2021-30); 国家自然科学基金(21662012); 海南省院士创新平台(YSPTZX202030); 及中央引导地方科技发展资金(ZY2022HN08)

收起

Anti-inflammatory Clerodane Diterpenoids from Polyalthia longifolia

  • Zhangxin Yu ,
  • Xinming Song ,
  • Yuan Yao ,
  • Jun Yang ,
  • Shuo Yang ,
  • Xiaobao Li
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
* Corresponding author. E-mail:

Received date: 2022-08-15

  Revised date: 2022-10-05

  Online published: 2022-11-01

Supported by

Natural Science Foundation of Hainan Province(221MS034); Natural Science Foundation of Hainan Province(220MS036); Key R&D Projects in Hainan Province-Social Development(ZDYF2022SHFZ286); Key R&D Projects in Hainan Province-Social Development(ZDYF2021SHFZ072); Education Department of Hainan Province(Hnky 2021-30); National Natural Science Foundation of China(21662012); Innovation Platform for Academicians of Hainan Province(YSPTZX202030); Central Government Guides Local Science and Technology Development(ZY2022HN08)

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摘要

对长叶暗罗茎的化学成分进行研究, 分离得到4个新的克罗烷型二萜类化合物, 通过NMR、HR-ESI-MS等多种现代波谱技术鉴定为: 2-氧代-14,15,16-降三碳克罗烷-3-烯-13-酸(1)、2-氧代-14,15,16-降三碳克罗烷-3-烯-13-甲酯(2)、2-氧代-14,15,16-降三碳克罗烷-3,11E-二烯-13-酸(3)、2-氧代-16-羟基-克罗烷-3,13Z-二烯-15-酸(4). 其中, 化合物1~3为降三碳克罗烷型二萜, 所有化合物均表现出一定的抗炎活性, IC50值范围为9.24~18.82 μmol/L.

关键词： 长叶暗罗; 克罗烷型二萜; 抗炎活性

本文引用格式

余章昕 , 宋鑫明 , 姚远 , 杨俊 , 杨硕 , 李小宝 . 长叶暗罗中克罗烷型二萜及其抗炎作用[J]. 有机化学, 2023 , 43(2) : 751 -755 . DOI: 10.6023/cjoc202208019

Abstract

Four new clerodane diterpenoids (1~4) were obtained from the stems of Polyalthia longifolia during a systematic phytochemical investigation. Their structures were elucidated comprehensive spectroscopic methods as 2-oxo-14,15,16-tri- norclerod-3-en-13-oic acid (1), 2-oxo-14,15,16-trinorclerod-3-en-13-methyl ester (2), 2-oxo-14,15,16-trinorclerod-3,11E- dien-13-oic acid (3), and 2-oxo-cleroda-3,13Z-dien-16-hydroxy-15-oic acid (4). Among them, compounds 1~3 are 14,15,16-norclerodane diterpenoids. The anti-inflammatory activity of mouse leukemia cells of monocyte macrophage (RAW 264.7) cells with lipopolysaccharide-induced was evaluated, and all the compounds showed potential anti-inflammatory activities with IC50 values ranged from 9.24 to18.82 μmol/L.

Key words： Polyalthia longifolia; clerodane diterpenes; anti-inflammatory

参考文献

[1]
Padmaa, M. P.; Khosa, R. L. J. Pharm. Res. 2009, 2, 594.
[2]
Goyal, M. M.; Gupta, A. Indian J. Pharmacol 1987, 19, 216.
[3]
Nguyen, M. V.; Han, J. W.; Le, D. Q.; Ryu, S. M.; Lee, D. H.; Kim, H.; Choi, G. J. J. Agric. Food Chem. 2021, 69, 10527.
[4]
Annan, K.; Ekuadzi, E.; Asare, C.; Sarpong, K.; Pistorius, D.; Oberer, L.; Gyan, B. A. O. Phytochem. Lett. 2015, 11, 28.
[5]
Kouam, S. F.; Ngouonpe, A. W.; Lamsh?ft, M.; Talontsi, F. M.; Bauer, J. O.; Strohmann, C.; Ngadiui, B. T.; Laatsch, H.; Spiteller, M. Phytochemistry 2014, 105, 52.
[6]
Yao, L. J.; Jalil, J.; Attiq, A.; Hui, C. C.; Zakaria, N. A. J. Ethnopharmacol. 2019, 229, 303.
[7]
Wu, T. H.; Cheng, Y. Y.; Chen, C. J.; Ng, L. T.; Chou, L. C.; Huang, L. J.; Chen, Y. H.; Kuo, S. C.; El-Shazly, M.; Wu, Y. C. Molecules 2014, 19, 2049.
[8]
Yu, Z. X.; Zheng, C. J.; Chen, G. Y.; Huang, R. L.; Zhou, X. M.; Niu, Z. G.; Li, X. B.; Han, C. R.; Song, X. P. J. Nat. Prod. 2019, 82, 27.
[9]
Yu, Z. X.; Zhuo, M. Y.; Li, X. B.; Fu, Y. H.; Chen, G. Y.; Song, X. P.; Han, C. R.; Song, M. X.; Fan, Q. J. Nat. Prod. Res. 2017, 31, 1687.
[10]
Salah, M. A.; Bedir, E.; Agric, J. Food Chem. 2003, 51, 7607.
[11]
He, H. P.; Shen, Y. M.; Zuo, G. Y.; Yang, X. S.; Hao, X. J. Helv. Chim. Acta 2003, 86, 3187.
[12]
Lee, T. H.; Wang, M. J.; Chen, P. Y.; Wu, T. Y.; Wen, W. C.; Tsai, F. Y.; Lee, C. K. J. Nat. Prod. 2009, 72, 1960.
[13]
Huang, X. J.; Tang, J. Q.; Li, M. M.; Liu, Q.; Li, Y. L.; Fan, C. L.; Pei, H.; Zhao, H. N.; Wang, Y.; Ye, W. C. J. Asian Nat. Prod. Res. 2014, 16, 770.
[14]
Yu, Z. X.; Wang, C. H.; Zheng, W.; Chen, D. L.; Yang, Y.; Liu, Y. Y.; Wei, J. H. Chin. Pharm. J. 2019, 54, 1946. (in Chinese)
[14]
(余章昕, 王灿红, 郑威, 陈德力, 杨云, 刘洋洋, 魏建和, 中国药学杂志, 2019, 54, 1946.)
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