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2023 , Vol. 43 >Issue 2: 436 - 454

DOI: https://doi.org/10.6023/cjoc202208020

综述与进展

以氨基氰为原料合成含氮化合物的研究进展

  • 吴江龙 ,
  • 王中杰 ,
  • 王晨宇 ,
  • 王彦 ,
  • 李红俊 ,
  • 罗辉 ,
  • 李昊 ,
  • 王富强 ,
  • 李典军 ,
  • 杨金会
展开
  • 宁夏大学化学化工学院/省部共建煤炭高效利用与绿色化工国家重点实验室 银川 750021
†共同第一作者

收稿日期: 2022-08-16

  修回日期: 2022-09-18

  网络出版日期: 2022-11-01

基金资助

部委级自然科学其他项目(2019NXZD1); 宁夏自治区科技攻关(支撑)计划(2021BEG02001); 宁夏自治区科技攻关(支撑)计划(2021BEE03003); 及宁夏自治区重点研发计划(2022BDE03009)

收起

Research Progress on the Synthesis of Nitrogen-Containing Compounds with Cyanamide as a Building Block

  • Jianglong Wu ,
  • Zhongjie Wang ,
  • Chenyu Wang ,
  • Yan Wang ,
  • Hongjun Li ,
  • Hui Luo ,
  • Hao Li ,
  • Fuqiang Wang ,
  • Dianjun Li ,
  • Jinhui Yang
Expand
  • College of Chemistry and Chemical Engineering/State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan 750021
†(These authors contributed equally to this work).
* Corresponding authors. E-mail: ;
;

Received date: 2022-08-16

  Revised date: 2022-09-18

  Online published: 2022-11-01

Supported by

Ministry-Level Natural Science Other Projects(2019NXZD1); Scientific and Technological Research (Support) Project of Ningxia(2021BEG02001); Scientific and Technological Research (Support) Project of Ningxia(2021BEE03003); Key Research and Development Project of Ningxia(2022BDE03009)

Fold

摘要

含氮化合物存在于许多天然产物中, 具有广泛的药理和生理活性. 它们不仅被广泛应用于医药或农药领域, 在工业及多功能材料等领域也多有应用. 近年来, 含氮化合物的合成方法研究发展迅速, 不断有新的以氨基氰为原料合成各种含氮化合物的反应涌现. 简要介绍了近二十年来, 以氨基氰(NH2-CN)作为原料合成各种含氮化合物的研究进展, 并归纳总结了它们的特点、规律和优劣势, 为它们的合成方法和反应性的研究提供帮助.

关键词： 氨基氰; 天然化合物; 含氮化合物; 药物分子

本文引用格式

吴江龙 , 王中杰 , 王晨宇 , 王彦 , 李红俊 , 罗辉 , 李昊 , 王富强 , 李典军 , 杨金会 . 以氨基氰为原料合成含氮化合物的研究进展[J]. 有机化学, 2023 , 43(2) : 436 -454 . DOI: 10.6023/cjoc202208020

Abstract

Nitrogen-containing compounds are widely found in many natural products and have a wide range of pharmaco- logical and physiological activities. Furthermore, they have comprehensive applications in medicine and pesticide fields, industry and multi-functional materials. Great advances in the synthesis of these compounds have been sprung up, a diversity of synthetic methods of them via cyanamide (NH2-CN) as raw material were exploited in recent years. The research progress on the synthesis of nitrogen-containing compounds through cyanamide as a building block is introduced comprehensively. Moreover, their characteristics, rules, advantages and disadvantages are summarized and discussed for the development of new synthetic methodologies and reactions of nitrogen-containing compounds.

Key words： cyanamide; natural origin; nitrogen-containing compound; pharmaceutical

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