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2022 , Vol. 42 >Issue 12: 4024 - 4036

DOI: https://doi.org/10.6023/cjoc202208039

综述与进展

光/电催化下2-芳基-2H-吲唑C-3位的官能团化反应

  • 王丹凤 ,
  • 汪瑾 ,
  • 马春华 ,
  • 姜玉钦 ,
  • 於兵
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  • a 河南师范大学化学化工学院 河南新乡 453007
    b 郑州大学化学学院 郑州 450001

收稿日期: 2022-08-28

  修回日期: 2022-10-13

  网络出版日期: 2022-11-08

基金资助

国家自然科学基金(82003585); 国家自然科学基金(21971224); 河南师范大学优秀科技创新团队(2022TD03); 中国国家级大学生创新创业训练计划(202210476076)

收起

C-3 Functionalization of 2-Aryl-2H-indazoles under Photo/Electrocatalysis

  • Danfeng Wang ,
  • Jin Wang ,
  • Chunhua Ma ,
  • Yuqin Jiang ,
  • Bing Yu
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  • a School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
    b College of Chemistry, Zhengzhou University, Zhengzhou 450001
*E-mail: ;
;

Received date: 2022-08-28

  Revised date: 2022-10-13

  Online published: 2022-11-08

Supported by

National Natural Science Foundation of China(82003585); National Natural Science Foundation of China(21971224); Technical Innovation Team of Henan Normal University(2022TD03); National College Students’ Innovation and Entrepreneurship Training Program of China(202210476076)

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摘要

2H-吲唑是一种广泛存在于多种上市药物和活性分子中的优势骨架, 对其骨架直接进行C—H键官能团化是构建其衍生物的有效方法之一, 已经成为当前合成化学和药物化学的研究热点. 相比传统的合成方法, 可见光/电化学促进的合成方法条件温和, 是一种环境友好的合成策略. 本文以催化体系分类, 综述了近年来光/电催化下2-芳基-2H-吲唑C-3位的官能团化反应, 特别强调相应的反应机理, 为进一步开发新型的催化方法奠定基础.

关键词： 2H-吲唑; 官能团化; 光催化; 电催化

本文引用格式

王丹凤 , 汪瑾 , 马春华 , 姜玉钦 , 於兵 . 光/电催化下2-芳基-2H-吲唑C-3位的官能团化反应[J]. 有机化学, 2022 , 42(12) : 4024 -4036 . DOI: 10.6023/cjoc202208039

Abstract

2H-Indazole is a privileged scaffold widely existing in drugs and bioactive molecules. The C—H functionalization of 2H-indazole is the cutting edge in medicinal chemistry and organic chemistry. Compared with traditional synthetic methods, the visible light/electrochemical-promoted synthetic method has mild conditions and is an environmentally friendly synthetic strategy. The C—H functionalization of 2-aryl-2H-indazoles at the C-3 position catalyzed by photochemical/electrochemical strategies in recent years is summarized in terms of catalytic systems, with special emphasis on the corresponding reaction mechanism, which might inspire the further development of new catalytic methods.

Key words： 2H-indazole; functionalization; photocatalysis; electrocatalysis

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