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2023 , Vol. 43 >Issue 4: 1591 - 1595

DOI: https://doi.org/10.6023/cjoc202208033

研究简报

地枫皮中一个新的单萜杂合苯丙素成分

  • 宁德生 ,
  • 符毓夏 ,
  • 李连春 ,
  • 邹芷琪 ,
  • 潘争红
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  • a 广西壮族自治区中国科学院广西植物研究所 广西植物功能物质与资源持续利用重点实验室 广西桂林 541006
    b 广西中医药大学药学院 南宁 530200

收稿日期: 2022-08-24

  修回日期: 2022-10-17

  网络出版日期: 2022-11-15

基金资助

国家自然科学基金(31960091); 广西创新驱动发展专项(桂科AA18118015); 广西自然科学基金(2018 GXNSFBA281094); 桂林市创新平台和人才计划(20210102-3)

收起

A New Monoterpene-Phenylpropanoid from Illicium difengpi

  • Desheng Ning ,
  • Yuxia Fu ,
  • Lianchun Li ,
  • Zhiqi Zou ,
  • Zhenghong Pan
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  • a Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy Sciences, Guilin, Guangxi 541006
    b College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200
* Corresponding author.

Received date: 2022-08-24

  Revised date: 2022-10-17

  Online published: 2022-11-15

Supported by

National Natural Science Foundation of China(31960091); Guangxi Innovation-driven Development Special Project(Guike AA18118015); Natural Science Foundation of Guangxi Province(2018 GXNSFBA281094); Guilin Innovation Platform and Talent Plant(20210102-3)

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摘要

采用多种柱色谱分离技术对地枫皮树皮进行深入的化学成分研究, 从其二氯甲烷部位中分离得到4个化合物, 并通过质谱(MS)、红外光谱(IR)、核磁共振光谱(NMR)等谱学技术和量子化学计算方法对其结构分别鉴定为地枫皮醇D (1)、(E)-3,4-亚甲二氧基苯丙烯醛(2)、二氢荜澄茄素(3)和pestalotiopyrone G (4). 化合物1是一个罕见的由链状单萜与苯丙素通过C—C杂合的新化合物, 为八角属植物中首个单萜杂合苯丙素类成分. 化合物1显示出弱的抗炎活性.

关键词： 地枫皮; 单萜杂合苯丙素; 结构鉴定; 绝对构型

本文引用格式

宁德生 , 符毓夏 , 李连春 , 邹芷琪 , 潘争红 . 地枫皮中一个新的单萜杂合苯丙素成分[J]. 有机化学, 2023 , 43(4) : 1591 -1595 . DOI: 10.6023/cjoc202208033

Abstract

Four compounds were isolated from the dichloromethane extract of stem bark of Illicium difengpi by using various column chromatographic methods. Their structures were identified as difengpienol D (1), (E)-3,4-methylenedioxophenyl propenal (2), dihydrocubebin (3) and pestalotiopyrone G (4) respectively by mass spectrometry (MS), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), etc. and quantum chemical calculation method. Compound 1 was an unusual new compound formed by acyclic monoterpenoid and phenylpropanoid through C—C chain, and was also the first monoterpene-phenylpropanoid isolated from the genus Illicium. It showed weak anti-inflammatory activity.

Key words： Illicium difengpi; monoterpene-phenylpropanoid; structural identification; absolute configuration

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