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2023 , Vol. 43 >Issue 6: 2081 - 2095

DOI: https://doi.org/10.6023/cjoc202210034

综述与进展

多信号同时检测生物硫醇荧光探针的研究进展

  • 刘甜甜 ,
  • 张鸿鹏 ,
  • 焦晓梦 ,
  • 白银娟
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  • 西北大学化学与材料科学学院 合成与天然功能分子教育部重点实验室 西安 710127

收稿日期: 2022-10-27

  修回日期: 2022-12-02

  网络出版日期: 2022-12-28

基金资助

国家自然科学基金(21042002)

收起

Research Progress of Multi-signal Fluorescent Probes for Simultaneous Detection of Biothiols

  • Tiantian Liu ,
  • Hongpeng Zhang ,
  • Xiaomeng Jiao ,
  • Yinjuan Bai
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  • Key Laboratory of Synthetic and National Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Material Science, Northwest University, Xi'an 710127
* E-mail:

Received date: 2022-10-27

  Revised date: 2022-12-02

  Online published: 2022-12-28

Supported by

National Natural Science Foundation of China(21042002)

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摘要

生物硫醇之间存在着密切的联系, 一种生物硫醇在特定的细胞代谢过程中发生的变化可能与另一种生物硫醇有关, 许多疾病也是两种或多种生物硫醇联合作用的结果. 利用荧光法同时检测多种生物硫醇对生物学研究和疾病诊断具有特别重要的意义. 近年来, 在这一领域出现了突破性的研究成果. 综述了多信号荧光探针在同步检测生物硫醇领域的研究进展. 根据探针所检测的对象进行系统分类讨论, 归纳和总结了相应探针的设计理念、光学性质、检测机制、识别性能和生物应用, 并对该领域的发展和应用前景做了展望.

关键词： 生物硫醇; 荧光探针; 同时检测; 多信号

本文引用格式

刘甜甜 , 张鸿鹏 , 焦晓梦 , 白银娟 . 多信号同时检测生物硫醇荧光探针的研究进展[J]. 有机化学, 2023 , 43(6) : 2081 -2095 . DOI: 10.6023/cjoc202210034

Abstract

There is a close relationship between different biothiols. The changes of one biothiol level in a specific cell metabolism process may be related to the variation of another biothiol, and many diseases are the result of the combination of two or more biothiols. The simultaneous detection of divers biological thiols by fluorescence method is of particular importance for biological research and disease diagnosis. In recent years, breakthrough results have been achieved in this field. The research progress of multi-signal fluorescent probes in the field of simultaneous detection of biothiols is reviewed. According to the objects detected by the probes, the fluorescent probes are systemically classified and discussed, and the corresponding design concept, optical properties, detection mechanism, recognition performance and biological applications are summarized. At the same time, the future development and application in this field are proposed.

Key words： biothiol; fluorescent probe; simultaneous detection; multi-signal

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