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2023 , Vol. 43 >Issue 6: 2096 - 2103

DOI: https://doi.org/10.6023/cjoc202212002

研究论文

烯胺酮平台构建转化生物质产品Cyrene为增值化合物

  • 黄丽珠 ,
  • 刘云云 ,
  • 万结平
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  • a 江西师范大学化学化工学院 国家单糖化学合成工程技术研究中心 南昌 330022
    b 南京林业大学林产化学与材料国际创新高地 南京 210037

收稿日期: 2022-12-03

  修回日期: 2023-01-06

  网络出版日期: 2023-01-18

基金资助

国家自然科学基金(22161022)

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Engineering Biomass Feedstock Cyrene to Value-Added Compounds by Enaminone Platform Construction

  • Lizhu Huang ,
  • Yunyun Liu ,
  • Jieping Wan
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  • a National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
    b International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037
* E-mail: ;

Received date: 2022-12-03

  Revised date: 2023-01-06

  Online published: 2023-01-18

Supported by

National Natural Science Foundation of China(22161022)

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摘要

发展了在二氢左旋葡萄糖酮(Cyrene, 昔兰尼)的酮α-位烯胺化构建烯胺昔兰尼(EC)的方法, 有效地构建烯胺Cyrene作为平台合成子为将生物质产品Cyrene转化为增值化学品开辟了广阔的空间. 在此研究中, 实现了将烯胺昔兰尼向多种不同的手性有机衍生物, 包括NH-/N,N-双取代结构的烯胺昔兰尼, 氰基烯-和烯基磷修饰的昔兰尼, 呋喃稠环结构的昔兰尼以及2,2-二氟二氢呋喃稠合的昔兰尼的转化.

关键词： 昔兰尼; 生物质产品; 烯胺化; 平台; 增值

本文引用格式

黄丽珠 , 刘云云 , 万结平 . 烯胺酮平台构建转化生物质产品Cyrene为增值化合物[J]. 有机化学, 2023 , 43(6) : 2096 -2103 . DOI: 10.6023/cjoc202212002

Abstract

The enamination of Cyrene in the ketone α-site leading to the enamino Cyrene (EC) has been developed. The practical preparation of EC as a platform synthon opens broad space of chemical transformation for Cyrene biomass feedstock in the synthesis of diverse value-added chemicals. In the present work, the transformation of the EC for the synthesis of many different chiral organic derivatives, including NH-/N,N-disubstituted ECs, the cyanoalkenyl- and vinyl phosphine oxide-elabo- rated Cyrene, Cyrene fused furan, and 2,2-difluorodihydrofuran fused Cyrene, has been realized.

Key words： Cyrene; biomass feedstock; enamination; platform; value-added

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