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2023 , Vol. 43 >Issue 7: 2519 - 2527

DOI: https://doi.org/10.6023/cjoc202211008

研究论文

铑催化3-重氮吲哚-2-亚胺与吡唑啉酮的C—H官能团化反应制备3-吡唑基吲哚

  • 许晓萍 ,
  • 张翼飞 ,
  • 莫小渝 ,
  • 江俊
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  • 广西大学化学化工学院 南宁 530004

收稿日期: 2022-11-08

  修回日期: 2023-01-17

  网络出版日期: 2023-02-15

基金资助

国家自然科学基金(22161005); 广西省自然科学基金(2021GXNSFDA075005); 中国科学院大连化学物理研究所分子反应动力学国家重点实验室开放基金(SKLMRD-K202106)

收起

Rh-Catalyzed C—H Functionalization Reaction between 3-Diazoindolin-2-imines and Pyrazolones for the Construction of 3-Pyrazolyl Indoles

  • Xiaoping Xu ,
  • Yifei Zhang ,
  • Xiaoyu Mo ,
  • Jun Jiang
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  • School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004
*E-mail:

Received date: 2022-11-08

  Revised date: 2023-01-17

  Online published: 2023-02-15

Supported by

National Natural Science Foundation of China(22161005); Natural Science Foundation of Guangxi Province(2021GXNSFDA075005); Open Fund of the State key Laboratory of Molecular Reaction Dynamics in Dalian Institute of Chemical Physics, Chinese Academy of Sciences(SKLMRD-K202106)

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摘要

报道了一种在Rh2(OAc)4存在下α-亚胺卡宾和吡唑啉酮的高效C—H官能团化反应. 该方法通过C—C键的形成为构建结构多样的3-吡唑基吲哚化合物提供了一种快速、直接的途径, 反应具有中等至优异的产率和良好的官能团耐受性.

关键词： 重氮化合物; 金属卡宾; C—H官能团化; 吡唑啉酮

本文引用格式

许晓萍 , 张翼飞 , 莫小渝 , 江俊 . 铑催化3-重氮吲哚-2-亚胺与吡唑啉酮的C—H官能团化反应制备3-吡唑基吲哚[J]. 有机化学, 2023 , 43(7) : 2519 -2527 . DOI: 10.6023/cjoc202211008

Abstract

A highly efficient C—H functionalization reaction of α-imino carbenes and pyrazolones in the presence of Rh2(OAc)4 has been reported. This methodology provides a rapid and straightforward approach toward a variety of structurally diverse 3-pyrazolyl indoles by C—C bond formation in moderate to excellent yields with good functional group tolerance.

Key words： diazo compounds; metal carbenes; C—H functionalization; pyrazolones

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