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2023 , Vol. 43 >Issue 7: 2567 - 2571

DOI: https://doi.org/10.6023/cjoc202212020

研究简报

裸花紫珠叶中两个新的半日花烷型二萜

  • 余章昕 ,
  • 蒙玉琴 ,
  • 薛萌琳 ,
  • 李小宝 ,
  • 陈光英 ,
  • 韩长日
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  • a海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 热带药用植物化学海南省重点实验室 海口 571158
    b海南科技职业大学 药食同源植物资源海南省重点实验室 海口 571126

收稿日期: 2020-12-15

  修回日期: 2023-01-29

  网络出版日期: 2023-03-07

基金资助

海南省重点研发项目(ZDYF2022SHFZ286); 海南省重点研发项目(ZDYF2021SHFZ072); 海南省自然科学基金(221MS034); 海南省教育厅项目(Hnky2021-30); 国家自然科学基金(21662012); 海南省院士创新平台(YSPTZX202030); 及中央引导地方科技发展资金(ZY2022HN08)

收起

Two New Labdane Diterpenoids from the Leaves of Callicarpa nudiflora

  • Zhangxin Yu ,
  • Yuqin Meng ,
  • Menglin Xue ,
  • Xiaobao Li ,
  • Guangying Chen ,
  • Changri Han
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  • aKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    bKey Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126
*E-mail: ;

Received date: 2020-12-15

  Revised date: 2023-01-29

  Online published: 2023-03-07

Supported by

Key R&D Projects in Hainan Province-Social Development(ZDYF2022SHFZ286); Key R&D Projects in Hainan Province-Social Development(ZDYF2021SHFZ072); Hainan Provincial Natural Science Foundation(221MS034); Education Department of Hainan Province(Hnky2021-30); National Natural Science Foundation of China(21662012); Innovation Platform for Academicians of Hainan Province(YSPTZX202030); Central Government Guides Local Science and Technology Development(ZY2022HN08)

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摘要

从裸花紫珠叶子中分离纯化得到2个新的半日花烷型二萜化合物3-氧代-7-羟基-半日花烷-8(17),13E-烯-15-酸(1)、3-氧代-8-羟基-半日花烷-13E-烯-15-酸(2)及5个已知的萜类化合物, 其结构通过核磁共振(NMR)、高分辨电喷雾电离质谱(HRESIMS)等多种现代波谱技术进行确定, 化合物1的绝对构型通过单晶衍射确定. 评价了所有化合物对脂多糖(LPS)诱导小鼠巨噬细胞RAW 264.7产生一氧化氮(NO)的抑制作用, 结果显示新化合物1和2表现出较好的抗炎活性, 其IC50值分别为(10.3±0.3)和(12.7±0.4) μmol/L.

关键词： 裸花紫珠; 半日花烷型二萜; 倍半萜

本文引用格式

余章昕 , 蒙玉琴 , 薛萌琳 , 李小宝 , 陈光英 , 韩长日 . 裸花紫珠叶中两个新的半日花烷型二萜[J]. 有机化学, 2023 , 43(7) : 2567 -2571 . DOI: 10.6023/cjoc202212020

Abstract

Two new labdane diterpenoids 3-oxo-7-hydroxy-8(17),13E-labdadien-15-oic acid (1), 3-oxo-8-hydroxy-13E-lab- den-15-oic acid (2), and five known terpenoids were obtained from the leaves of Callicarpa nudiflora during a systematic phytochemical investigation. The structures were elucidated using comprehensive spectroscopic methods [nuclear magnetic resonance spectroscopy (NMR) and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS)], and the absolute configuration of 1 was established based on single-crystal X-ray diffraction. The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced (LPS) mouse leukemia cells of monocyte macrophage (RAW 264.7) cells was evaluated. Compounds 1 and 2 showed potential anti-inflammatory activity with IC50 values of (10.3±0.3) and (12.7±0.4) μmol/L, respectively.

Key words： C. nudiflora; labdane diterpenes; sesquiterpenes

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