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2023 , Vol. 43 >Issue 8: 2878 - 2884

DOI: https://doi.org/10.6023/cjoc202301003

研究论文

高选择性比率型荧光探针用于急性肺损伤中次氯酸的检测

  • 丁炳辉 ,
  • 韩少辉 ,
  • 熊海青 ,
  • 王本花 ,
  • 左伯军 ,
  • 宋相志
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  • a 中南大学化学化工学院 长沙 410083
    b 山东农药科学研究院 济南 250033

收稿日期: 2023-01-04

  修回日期: 2023-03-12

  网络出版日期: 2023-04-14

基金资助

国家自然科学基金(22178395)

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A Highly Selective Ratiometric Fluorescent Probe for the Detection of Hypochlorite in Acute Lung Injury

  • Binghui Ding ,
  • Shaohui Han ,
  • Haiqing Xiong ,
  • Benhua Wang ,
  • Bojun Zuo ,
  • Xiangzhi Song
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  • a College of Chemistry & Chemical Engineering, Central South University, Changsha 410083
    b Shandong Academy of Pesticide Sciences, Jinan 250033
*E-mail: ;

Received date: 2023-01-04

  Revised date: 2023-03-12

  Online published: 2023-04-14

Supported by

The National Natural Science Foundation of China(22178395)

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摘要

检测急性肺损伤中过表达的次氯酸要求荧光探针具有很高的选择性. 合成了一种羟基萘香豆素探针NaphCou, 可以高选择性比值型检测次氯酸, 响应速度快, 发射波长长(从绿色到红色变化), Stokes位移大(从107 nm到155 nm). 利用该荧光探针, 成功监测了脂多糖诱导急性肺损伤小鼠中次氯酸的浓度变化.

关键词： 急性肺损伤; 次氯酸; 荧光探针; 比值型

本文引用格式

丁炳辉 , 韩少辉 , 熊海青 , 王本花 , 左伯军 , 宋相志 . 高选择性比率型荧光探针用于急性肺损伤中次氯酸的检测[J]. 有机化学, 2023 , 43(8) : 2878 -2884 . DOI: 10.6023/cjoc202301003

Abstract

The fluorescent probe for the detection of overexpressed ClO－ in acute lung injury is required to have high selectivity against other reactive species. A hydroxybenzo[g]coumarin, NaphCou, was synthesized as a ratiometric fluorescent probe to detect ClO－ with ultra-high selectivity, a fast response, long-wavelength emissions (from green to red) and large Stokes shifts (from 107 nm to 155 nm). Using probe NaphCou as a fluorescence sensing tool, the lipopolysaccharide (LPS)-induced acute lung injury in mouse model was investigated by monitoring the hypochlorous acid concentration variation.

Key words： acute lung injury; hypochlorous acid; fluorescent probe; ratiometric measurement

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