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2023 , Vol. 43 >Issue 8: 2855 - 2863

DOI: https://doi.org/10.6023/cjoc202302004

研究论文

电化学介导羧酸与醇的酯化反应

  • 钟赟哲 ,
  • 陈颖 ,
  • 俞磊 ,
  • 周宏伟
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  • a 浙江师范大学化学与材料科学学院 浙江金华 321004
    b 嘉兴学院生物与化学工程学院 浙江嘉兴 314001
    c 扬州大学化学化工学院 江苏扬州 225002

收稿日期: 2023-02-05

  修回日期: 2023-03-24

  网络出版日期: 2023-04-23

基金资助

国家自然科学基金(22071082)

收起

Electrochemical Mediated Esterification Reaction of Carboxylic Acids and Alcohols

  • Yunzhe Zhong ,
  • Ying hen ,
  • Lei Yu ,
  • Hongwei Zhou
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  • a College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang 321004
    b College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001
    c School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Zhejiang 225002
*E-mail: ;

Received date: 2023-02-05

  Revised date: 2023-03-24

  Online published: 2023-04-23

Supported by

The National Natural Science Foundation of China(22071082)

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摘要

通过电化学介导羧酸和醇反应合成了一系列酯类化合物. 该策略通过温和绿色的电化学合成方式进行, 反应在室温下即可发生, 无需惰性气体保护, 过程中也无需使用强酸和金属催化剂等进行辅助催化. 反应在无隔膜电解槽中以恒流模式进行, 以较高的收率生成酯化产物. 相比有机试剂促进的酯化反应, 该方案不残留需柱层析分离的副产物, 可适用难于反应的叔丁醇.

关键词： 电化学介导; 酯化反应; 有机电合成

本文引用格式

钟赟哲 , 陈颖 , 俞磊 , 周宏伟 . 电化学介导羧酸与醇的酯化反应[J]. 有机化学, 2023 , 43(8) : 2855 -2863 . DOI: 10.6023/cjoc202302004

Abstract

A series of esters were prepared by electrochemical synthesis of carboxylic acids with alcohols. This protocol can be carried out at room temperature without inert atmosphere, strong acids or metal catalysts, etc. The esterification reaction processes in an undivided electrolytic cell with constant current mode and the esterification products are generated in good yields. Compared with esterification promoted by organic reagents, this protocol avoids the byproducts which have to be separated by column chromatography and successful for tertiary alcohol which is generally difficult to undergo esterification directly, providing a new access to the esterification of carboxylic acids and alcohols.

Key words： electrochemical mediation; esterification reaction; electromechanical synthesis

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