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2023 , Vol. 43 >Issue 9: 3319 - 3322

DOI: https://doi.org/10.6023/cjoc202303033

研究简报

禾谷镰刀菌中一个新的聚酮类化合物

  • 丁卫忠 ,
  • 张炳文 ,
  • 薛彦青 ,
  • 林雨琦 ,
  • 汤志军 ,
  • 王婧 ,
  • 杨文超 ,
  • 王晓峰 ,
  • 刘文
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  • a 中国科学技术大学化学系 合肥 230026
    b 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079
    c 国科大杭州高等研究院 化学与材料科学学院 杭州 310024
    d 中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032
† 共同第一作者.

收稿日期: 2023-03-22

  修回日期: 2023-04-25

  网络出版日期: 2023-05-06

基金资助

科技部重大专项(2022YFC2303100); 国家自然科学基金(22193070); 国家自然科学基金(32030002); 浙江省博士后科研项目择优资助项目

收起

A New Polyketide from Fusarium graminearum

  • Weizhong Ding ,
  • Bingwen Zhang ,
  • Yanqing Xue ,
  • Yuqi Lin ,
  • Zhijun Tang ,
  • Jing Wang ,
  • Wenchao Yang ,
  • Xiaofeng Wang ,
  • Wen Liu
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  • a Department of Chemistry, University of Science and Technology of China, Hefei 230026
    b Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079
    c School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024
    d State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032
† These authors contributed equally to this work.
* E-mail: ;

Received date: 2023-03-22

  Revised date: 2023-04-25

  Online published: 2023-05-06

Supported by

National Key Research and Development Program of China(2022YFC2303100); National Natural Science Foundation of China(22193070); National Natural Science Foundation of China(32030002); Postdoctoral Science Preferential Funding of Zhejiang Province

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摘要

镰刀菌属真菌能产生结构多样的活性天然产物. 对该属真菌Fusarium graminearum培养物的萃取物进行化学成分研究, 从中分离得到一个新的聚酮类化合物, 并将其命名为fusarane A (1). 综合运用高分辨质谱、一维、二维的核磁共振波谱和X射线单晶衍射方法对化合物1的结构进行了鉴定. 从结构上看, 化合物1具有少见的共轭多烯片段, 并且其所有的双键构型都为E构型. 此外, 生物活性测试结果表明, 在联用具有增强抗生素活性的佐剂双硫仑(10 μg/mL)时, 化合物1对金黄色葡萄球菌S. aureus ATCC 29213有潜在的抗菌活性, 最小抑菌浓度为32 μg/mL.

关键词： 禾谷镰刀菌; 天然产物; 聚酮; 抗菌活性

本文引用格式

丁卫忠 , 张炳文 , 薛彦青 , 林雨琦 , 汤志军 , 王婧 , 杨文超 , 王晓峰 , 刘文 . 禾谷镰刀菌中一个新的聚酮类化合物[J]. 有机化学, 2023 , 43(9) : 3319 -3322 . DOI: 10.6023/cjoc202303033

Abstract

The fungus Fusarium species is well known for producing bioactive natural products with diverse structures. A chemical investigation on the cultures extract of the Fusarium graminearum led to the isolation of one new polyketide, fusarane A (1). Its structure was elucidated on the basis of extensive HRESIMS, 1D and 2D-NMR spectra data analysis, and single-crystal X-ray diffraction. Structurally, compound 1 has a rare conjugated polyene moiety in which configurations of all double bonds were determined to be E. Furthermore, 1 showed potent inhibitory activity against S. aureus ATCC 29213 with the MIC value of 32 μg/mL when assayed in combination with disulfram (10 μg/mL), an established antibiotic adjuvant that augmented the activity of antibiotics.

Key words： Fusarium graminearum; natural product; polyketide; antibacterial activity

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