无支持电解质条件下连续流电化学合成三氟甲基化氧化吲哚
收稿日期: 2023-01-29
修回日期: 2023-05-07
网络出版日期: 2023-05-25
基金资助
上海市自然科学基金(20ZR1471600); 上海市科学技术委员会(19DZ2271100); 中国科学院能量调控材料重点实验室开放基金(ORFP2020-06)
Supporting-Electrolyte-Free Electrochemical Synthesis of Trifluoromethylated Oxindoles in Continuous Flow
Received date: 2023-01-29
Revised date: 2023-05-07
Online published: 2023-05-25
Supported by
Natural Science Foundation of Shanghai(20ZR1471600); Science and Technology Commission of Shanghai Municipality(19DZ2271100); Open Research Fund Program of CAS Key Laboratory of Energy Regulation Materials(ORFP2020-06)
岁丹丹 , 岑南楠 , 龚若蕖 , 陈阳 , 陈文博 . 无支持电解质条件下连续流电化学合成三氟甲基化氧化吲哚[J]. 有机化学, 2023 , 43(9) : 3239 -3245 . DOI: 10.6023/cjoc202301023
A supporting electrolyte-free method for the electrochemical synthesis of trifluoromethylated oxindoles in conti- nuous flow was developed. Various N-arylacrylamides reacted with CF3SO2NHNHBoc smoothly to provide the corresponding products in moderate yields. The reaction scale-up was easily realized without changing the reaction conditions, which showed the application potential of continuous flow electrochemical synthesis.
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