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2023 , Vol. 43 >Issue 7: 2293 - 2303

DOI: https://doi.org/10.6023/cjoc202304014

综述与进展

光/电化学驱动螺环化合物的合成研究进展

  • 陈宁 ,
  • 张成栋 ,
  • 李鹏 ,
  • 仇格 ,
  • 刘颖杰 ,
  • 张天雷
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  • a哈尔滨商业大学药学院 哈尔滨 150076
    b黑龙江护理高等专科学校 哈尔滨 150086
    c烟台大学化学化工学院 山东烟台 264005

收稿日期: 2023-04-10

  修回日期: 2023-06-05

  网络出版日期: 2023-06-26

基金资助

黑龙江省博士后科研启动金(LBH-Q20103); 高校学科协同创新成果建设培育(LJGXCG2022-086)

收起

Research Progress in Synthesis of Spirocyclic Compounds Driven by Photo/Electrochemistry

  • Ning Chen ,
  • Chengdong Zhang ,
  • Peng Li ,
  • Ge Qiu ,
  • Yinjie Liu ,
  • Tianlei Zhang
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  • aSchool of Pharmacy, Harbin University of Commerce, Harbin 150076
    bHeilongjiang Nursing College, Harbin 150086
    cSchool of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005
*E-mail: ;

Received date: 2023-04-10

  Revised date: 2023-06-05

  Online published: 2023-06-26

Supported by

Heilongjiang Postdoctoral Scientific Research Development Fund(LBH-Q20103); the Construction and Cultivation Project of Collaborative Innovation Achievements of University Disciplines(LJGXCG2022-086)

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摘要

螺环作为一种重要的有机分子骨架, 在有机化学、药物化学、材料科学等领域中广泛存在. 由于螺环骨架具有较大的三维空间结构, 满足药物设计中对构象刚性的需求, 因此开发高效的螺环化合物的合成方法尤为重要. 近年来, 光催化和电催化作为绿色、高效的合成手段, 为螺环化合物的合成注入了新的潜力. 主要按螺[4.5]类骨架、螺[5.5]类骨架、螺[2.3]类骨架以及螺吲哚类骨架的构建进行了分类, 并从光催化和电催化合成两个方面对螺环化合物的构建进行了综述.

关键词： 螺环; 光催化

本文引用格式

陈宁 , 张成栋 , 李鹏 , 仇格 , 刘颖杰 , 张天雷 . 光/电化学驱动螺环化合物的合成研究进展[J]. 有机化学, 2023 , 43(7) : 2293 -2303 . DOI: 10.6023/cjoc202304014

Abstract

As important organic molecular frameworks, spirocycles exist widely in organic chemistry, medicinal chemistry, material science and other fields. Since the spirocyclic skeleton has a large three-dimensional space structure, which meets the demand for conformational rigidity in drug design, it is particularly important to develop efficient synthetic methods for spirocyclic compounds. In recent years, photocatalysis and electrocatalysis have injected new potential into the synthesis of spirocyclic compounds as green and efficient synthetic methods. This article is mainly classified by the construction of snail [4.5] skeleton, snail [5.5] skeleton, snail [2.3] skeleton, and spiro-indoles skeleton. Moreover, the construction of spirocyclic compounds is reviewed from two aspects: photocatalysis and electrocatalytic synthesis.

Key words： spirocycles; photocatalysis

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