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2023 , Vol. 43 >Issue 12: 4227 - 4238

DOI: https://doi.org/10.6023/cjoc202304003

研究论文

锡粉促进下1,3-二取代-1,3-二氢异苯并呋喃化合物的合成

  • 唐朵朵 ,
  • 黄丹凤 ,
  • 王克虎 ,
  • 马虎 ,
  • 冯杨 ,
  • 任园园 ,
  • 王君姣 ,
  • 胡雨来
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  • 西北师范大学化学化工学院 兰州 730070

收稿日期: 2023-04-04

  修回日期: 2023-06-05

  网络出版日期: 2023-08-15

基金资助

国家自然科学基金(21861033); 国家自然科学基金(22061037)

收起

Tin Powder-Promoted Synthesis of 1,3-Disubstituted 1,3-Dihydroisobenzofuran Compounds

  • Duoduo Tang ,
  • Danfeng Huang ,
  • Kehu Wang ,
  • Hu Ma ,
  • Yang Feng ,
  • Yuanyuan Ren ,
  • Junjiao Wang ,
  • Yulai Hu
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  • College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
*

Received date: 2023-04-04

  Revised date: 2023-06-05

  Online published: 2023-08-15

Supported by

National Natural Science Foundation of China(21861033); National Natural Science Foundation of China(22061037)

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摘要

探究了锡粉促进下邻甲酰基查尔酮与烯丙基溴的串联烯丙基化/oxa-Michael加成反应, 为合成具有潜在生物活性的1,3-二取代-1,3-二氢异苯并呋喃提供了简便的方法. 该方法具有反应时间短, 操作简单, 产率优良等优点, 并进一步拓宽了锡粉促进下的反应类型．

关键词： 锡粉; 烯丙基溴; 邻甲酰基查尔酮; 1,3-二氢异苯并呋喃

本文引用格式

唐朵朵 , 黄丹凤 , 王克虎 , 马虎 , 冯杨 , 任园园 , 王君姣 , 胡雨来 . 锡粉促进下1,3-二取代-1,3-二氢异苯并呋喃化合物的合成[J]. 有机化学, 2023 , 43(12) : 4227 -4238 . DOI: 10.6023/cjoc202304003

Abstract

An efficient approach for the construction of 1,3-disubstituted-1,3-dihydroisobenzofuran compounds was developed through tin powder mediated tandem allylation/oxa-Michael addition reaction of o-formyl chalcones with various allyl bromides under mild reaction conditions. This method is easy to operate and can tolerate various functional groups to give the corresponding 1,3-disubstituted-1,3-dihydroisobenzofuran compounds in good to excellent yields.

Key words： tin powder; allyl bromide; o-formyl chalcone; 1,3-dihydroisobenzofuran

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