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2024 , Vol. 44 >Issue 1: 18 - 40

DOI: https://doi.org/10.6023/cjoc202306003

综述与进展

含双杂原子苯并[d]五元杂环硫醚类化合物的合成研究进展

  • 贾小英 ,
  • 普佳霞 ,
  • 韩丽荣 ,
  • 李清寒
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  • a 西南民族大学化学与环境学院 成都 610041
    b 西南民族大学 国家民委化学基础重点实验室 成都 610041

收稿日期: 2023-06-02

  修回日期: 2023-07-28

  网络出版日期: 2023-08-30

基金资助

西南民族大学中央高校学生项目(2022NYXXS081); 及国家民委基础化学重点实验室平台建设(ZYN2023106)

收起

Research Progress in the Synthesis of Benzo[d]pentamembered Heterocyclic Thioethers Containing Two Heteroatoms

  • Xiaoying Jia ,
  • Jiaxia Pu ,
  • Lirong Han ,
  • Qinghan Li
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  • a College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041
    b Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041
*E-mail:

Received date: 2023-06-02

  Revised date: 2023-07-28

  Online published: 2023-08-30

Supported by

Central University Foundation Student Program of Southwest Minzu University(2022NYXXS081); the Key Laboratory of General Chemistry of the National Ethnic Affairs Commission Support Program(ZYN2023106)

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摘要

具有双杂原子的苯并[d]噻唑/噁唑/咪唑等苯并[d]五元杂环硫醚结构广泛存在于许多药物分子和天然产物分子中, 其衍生物具有抗菌、抗病毒及抗肿瘤等广泛的生物活性, 同时也是有机合成的重要中间体及药物合成的结构单元. 因此, 苯并[d]噻唑/噁唑/咪唑硫醚化合物在医药、材料等领域具有极大的应用价值. 其合成方法的研究也成为当前的研究热点之一. 综述了近年来具有双杂原子的苯并[d]五元杂环硫醚类化合物的合成方法及其生物活性研究进展, 并对其部分反应机理做了相应的阐述.

关键词： 苯并[d]噻唑硫醚; 苯并[d]噁唑硫醚; 苯并[d]咪唑硫醚; C—S键形成; 研究进展

本文引用格式

贾小英 , 普佳霞 , 韩丽荣 , 李清寒 . 含双杂原子苯并[d]五元杂环硫醚类化合物的合成研究进展[J]. 有机化学, 2024 , 44(1) : 18 -40 . DOI: 10.6023/cjoc202306003

Abstract

The thioether structure of benzo[d]penta-membered heterocycles with double heteroatoms, such as benzo[d] thiazole/oxazole/imidazole, widely exists in many drug molecules and natural product molecules. Its derivatives have extensive biological activities such as antibacterial, antiviral and anti-tumor, and are also important intermediates in organic synthesis and structural units in drug synthesis. Therefore, benzo[d]thiazole/oxazole/imidazole sulfide compounds have great application value in medicine, materials and other fields. The research of its synthesis method has also become one of the current research hotspots. The synthesis methods and biological activity research progress of benzo[d]five membered heterocyclic sulfide compounds with double heteroatoms in recent years are reviewed, and some of their reaction mechanisms are described.

Key words： benzo[d]thiazole sulfide; benzo[d]oxazole sulfide; benzo[d]imidazole sulfide; C—S bond formation; research progress

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