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2024 , Vol. 44 >Issue 4: 1264 - 1275

DOI: https://doi.org/10.6023/cjoc202310002

研究论文

三氟甲硫基自由基引发涉及烯烃、AgSCF3和喹喔啉酮的三组分反应

  • 高燊原 ,
  • 诸昊穹 ,
  • 金巧玲 ,
  • 金露儿 ,
  • 王晓钟 ,
  • 戴立言
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  • 浙江大学化学与生物工程学院 浙江省先进化工制造技术重点实验室 杭州 310027

收稿日期: 2023-10-03

  修回日期: 2023-11-20

  网络出版日期: 2023-12-08

基金资助

浙江省先进化工制造技术重点实验室(2017E10001)

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Three-Component Reaction Involving Alkenes, AgSCF3 and Quinoxalinones Initiated by Trifluoromethylthio Radical

  • Shenyuan Gao ,
  • Haoqiong Zhu ,
  • Qiaoling Jin ,
  • Lu'er Jin ,
  • Xiaozhong Wang ,
  • Liyan Dai
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  • Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027
* E-mail: ;

Received date: 2023-10-03

  Revised date: 2023-11-20

  Online published: 2023-12-08

Supported by

Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology(2017E10001)

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摘要

提出了一种新的非活化烯烃、喹喔啉酮和AgSCF3的三组分级联自由基反应. 在氧化剂K2S2O8的作用下, 得到了40个含SCF3的喹喔啉酮类衍生物, 其中产率最高至78%. 该方法是一种在温和条件下制备含三氟甲硫基喹唑啉酮类化合物, 具有产率高、底物范围广、原子经济性高和环保高效等优势.

关键词： 三氟甲烷硫醇银; 自由基; 三组分反应

本文引用格式

高燊原 , 诸昊穹 , 金巧玲 , 金露儿 , 王晓钟 , 戴立言 . 三氟甲硫基自由基引发涉及烯烃、AgSCF3和喹喔啉酮的三组分反应[J]. 有机化学, 2024 , 44(4) : 1264 -1275 . DOI: 10.6023/cjoc202310002

Abstract

A novel three-component cascade radical reaction involving non-activated olefins, quinoxalin-2(1H)-ones, and AgSCF3 was proposed. Under the action of the oxidizing agent K2S2O8, 40 quinoxaline derivatives containing SCF3 were obtained with the highest yield of 78%. This method provides a mild and environmentally friendly approach to prepare trifluoromethylthio-substituted quinoxalines, offering advantages such as high yield, broad substrate scope, atom economy, and environmental efficiency.

Key words： (trifluoromethylthio) silver(I); radical; three-component reaction

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