Na2S2O8介导的咪唑并[1,2-α]吡啶与杂芳胺在无金属条件下的C—H胺化反应
收稿日期: 2023-11-24
修回日期: 2024-01-02
网络出版日期: 2024-01-12
基金资助
国家自然科学基金(21772107); 山东省高等学校青创人才引育计划(2021)
Na2S2O8 Mediated C—H Amination of Imidazo[1,2-α]pyridines with Heteroaromatic Amines under Metal-Free Conditions
Received date: 2023-11-24
Revised date: 2024-01-02
Online published: 2024-01-12
Supported by
National Natural Science Foundation of China(21772107); Youth Innovation Team Project for Talent Introduction and Cultivation in Universities of Shandong Province(2021)
发展了一种高效实用的氨化咪唑[1,2-α]吡啶类化合物的方法. 值得注意的是, 该反应无需任何金属催化剂参与. 在中等至高收率下, 成功得到了带有多样取代基的产物.
关键词： 咪唑[1,2-α]吡啶; 过硫酸盐; 杂芳胺; 绿色有机合成
孙一平 , 陈德茂 , 何玲 , 王祖利 . Na2S2O8介导的咪唑并[1,2-α]吡啶与杂芳胺在无金属条件下的C—H胺化反应[J]. 有机化学, 2024 , 44(5) : 1667 -1674 . DOI: 10.6023/cjoc202311026
A highly efficient and practical amination protocol for imidazo[1,2-α]pyridines using heteroaromatic amines was developed. Notably, the transformation proceeds without the need for any metal catalyst. Isolation of products bearing diverse substituents was achieved in moderate to high yields.
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