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DOI: https://doi.org/10.6023/cjoc202403002

研究论文

NBS促进的P(O)-H化合物参与的醇的直接磷酸化反应

  • Wang ,
  • Huabin ,
  • Xu ,
  • Lianhua ,
  • Liu ,
  • Xiongwei ,
  • Pan ,
  • Bowen ,
  • Yao ,
  • Zhen ,
  • Huang ,
  • Qiang ,
  • Zhou ,
  • Ying
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  • a贵州中医药大学 药学院 贵阳 550025
    b遵义医科大学 药学院 遵义 563000
†共同第一作者

收稿日期: 2024-04-15

  修回日期: 2024-05-08

  网络出版日期: 2024-05-23

基金资助

贵州省中医药管理局课题(No.QZYY-2021-008)资助项目, 国家自然科学基金(No.82360679)资助项目, 贵州省基础研究项目(自然科学方向)(黔科合基础-ZK[2022]一般592)资助项目.

收起

NBS-Promoted Direct Phosphorylation of Alcohols with P(O)-H Compounds

  • 王华斌 ,
  • 徐连华 ,
  • 刘雄伟 ,
  • 潘博文 ,
  • 姚震 ,
  • 黄强 ,
  • 周英
Expand
  • aGuizhou University of Traditional Chinese Medicine, College of pharmacy, Guiyang 550025, China
    bZunyi Medical University, School of Pharmacy, Zunyi 563000, China
†These authors contributed equally to this work.

Received date: 2024-04-15

  Revised date: 2024-05-08

  Online published: 2024-05-23

Supported by

Guizhou Province Administration of Traditional Chinese Medicine Project (No.QZYY-2021-008).Chinese National Natural Science Foundation (No.82360679). Guizhou Provincial Basic Research Program(Natural Science) (QKHJC-ZK[2022] General 592).

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摘要

发展了一种温和、绿色、便捷和可扩大的N-溴代丁二酰亚胺（NBS）促进的次级膦氧化合物与醇的直接磷酸化策略用于合成多种次磷酸酯。底物适用范围广泛且耐受性好,能以中等至优异的收率(高达92%)合成目标化合物。该反应在室温下进行,无需添加任何氧化剂和金属催化剂,这为次磷酸酯衍生物的合成提供了一种新的策略。

关键词： 磷酸化; P-O键; 次磷酸酯; 醇; NBS

本文引用格式

Wang , Huabin , Xu , Lianhua , Liu , Xiongwei , Pan , Bowen , Yao , Zhen , Huang , Qiang , Zhou , Ying . NBS促进的P(O)-H化合物参与的醇的直接磷酸化反应[J]. 有机化学, 0 : 0 . DOI: 10.6023/cjoc202403002

Abstract

A mild, green, convenient and scalable N-Bromosuccinimide (NBS) promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed. A variety of substrates were well-tolerated and afforded the desirable compounds in moderate to excellent yields (up to 92%). This reaction was conducted at room temperature without the addition of any oxidant and metal catalyst, which provides a new strategy for the synthesis of phosphinate esters.

Key words： Phosphorylation; P-O bond; Phosphinate esters; Alcohols; NBS

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