聚集诱导发光材料在肿瘤光治疗应用中的最新进展
Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy
Received date: 2024-03-31
Revised date: 2024-06-14
Online published: 2024-07-02
癌症是世界上导致死亡的主要原因之一, 其发病率不断上升. 光疗以其无创、无耐受性、副作用小和操作方便等优势, 已成为癌症精准治疗的新范式. 自2001年唐本忠院士团队发现聚集诱导发光(AIE)现象以来, 具有该性质的荧光材料被广泛用作高效光敏/光热试剂. 因其高度扭曲的分子结构, 避免了聚集态下的平面堆叠问题, 从根本上解决了传统荧光材料聚集淬灭现象, 显著提高了量子产率和光稳定性. 作者详细对AIE材料作为光敏剂、光热剂及显影剂在癌症光疗(光动力治疗、光热治疗和光声成像)以及联合治疗中的最新应用进行了综述, 并展望其未来发展趋势.
孟子翔 , 田秀梅 , 张天富 . 聚集诱导发光材料在肿瘤光治疗应用中的最新进展[J]. 有机化学, 2024 , 44(8) : 2441 -2452 . DOI: 10.6023/cjoc202403058
Cancer is a leading cause of death globally with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, no drug resistance, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.
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