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2024 , Vol. 44 >Issue 11: 3409 - 3416

DOI: https://doi.org/10.6023/cjoc202405008

研究论文

以N,N-二甲基乙醇胺为单碳合成子构建3,5-二芳基吡啶的新方法

  • 张鑫宇 ,
  • 陈静 ,
  • 马永敏
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  • a 浙江中医药大学药学院 杭州 310053
    b 台州学院药学院 浙江台州 318000

收稿日期: 2024-05-07

  修回日期: 2024-05-24

  网络出版日期: 2024-07-02

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Construction of 3,5-Diarylpyridine Derivatives Using N,N-Dimethyl-ethanolamine as a Single-Carbon Synthon

  • Xinyu Zhang ,
  • Jing Chen ,
  • Yongmin Ma
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  • a School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053
    b School of Pharmaceutical Sciences, Taizhou University, Taizhou, Zhejiang 318000
*Corresponding author. E-mail:

Received date: 2024-05-07

  Revised date: 2024-05-24

  Online published: 2024-07-02

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摘要

开发了一种以苯乙炔或苯乙醛, 氯化铵和N,N-二甲基乙醇胺为原料, 在140 ℃条件下经三氟甲磺酸铁催化发生[2＋2＋1＋1]环化反应, 其中N,N-二甲基乙醇胺既作为溶剂又作为单碳合成子参与构建3,5二芳基吡啶类化合物.

关键词： 3,5-二芳基吡啶; N,N-二甲基乙醇胺; 单碳合成子; 铁催化; 环合反应

本文引用格式

张鑫宇 , 陈静 , 马永敏 . 以N,N-二甲基乙醇胺为单碳合成子构建3,5-二芳基吡啶的新方法[J]. 有机化学, 2024 , 44(11) : 3409 -3416 . DOI: 10.6023/cjoc202405008

Abstract

3,5-Diarylpyridines were effectively synthesized via [2＋2＋1＋1] cyclization reaction catalyzed by Fe(OTf)3 at 140 ℃, using phenylacetylenes or phenylacetaldehydes, ammonium chloride and N,N-dimethylethanolamine as starting materials. N,N-Dimethylethanolamine was employed as both solvent and a single carbon synthon.

Key words： 3,5-diarylpyridine; N,N-dimethylethanolamine; single carbon synthon; iron catalyzed; cyclization

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