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2024 , Vol. 44 >Issue 8: 2581 - 2587

DOI: https://doi.org/10.6023/cjoc202403043

研究论文

四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu2＋

  • 苏小龙 ,
  • 李健鹏 ,
  • 刘孟鑫 ,
  • 邹莉 ,
  • 杨得锁 ,
  • 冯海涛
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  • 宝鸡文理学院化学化工学院 聚集诱导发光研究中心 陕西宝鸡 721000

收稿日期: 2024-03-27

  修回日期: 2024-05-23

  网络出版日期: 2024-07-15

基金资助

国家自然科学基金(52173152); 国家自然科学基金(21805002); 陕西省科技创新团队(2022TD-36); 陕西省自然科学基金(2024JC-YBMS-123); 陕西省教育厅服务地方(23JC001)

收起

Synthesis of Tetraphenylethylene Based Amides for Detection of Copper(II) Ion with High Sensitivity and Selectivity

  • Xiaolong Su ,
  • Jianpeng Li ,
  • Mengxin Liu ,
  • Li Zou ,
  • Desuo Yang ,
  • Haitao Feng
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  • Aggregation-Induced Emission Research Center, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, Shaanxi 721000
*E-mail: ;

Received date: 2024-03-27

  Revised date: 2024-05-23

  Online published: 2024-07-15

Supported by

National Natural Science Foundation of China(52173152); National Natural Science Foundation of China(21805002); Scientific and Technological Innovation Team of Shaanxi Province(2022TD-36); Natural Science Foundation of Shaanxi Province(2024JC-YBMS-123); Service Local Projects in Shaanxi Provincial Education Department(23JC001)

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摘要

设计合成了一种四苯乙烯基酰胺类荧光探针TPE-Py, 并对其结构进行了表征. 通过荧光发射光谱和HeLa细胞成像实验研究了其金属离子识别性能. 结果表明: 探针TPE-Py对Cu2＋具有较好的选择性和灵敏性, 在H2O/THF (V∶ V=9∶1)溶液中对Cu2＋显示出荧光淬灭效应, 且不受其他金属离子干扰. 细胞成像实验表明, 探针TPE-Py可以检测细胞脂滴中的Cu2＋.

关键词： 聚集诱导发光; 荧光探针; 离子识别; 细胞成像

本文引用格式

苏小龙 , 李健鹏 , 刘孟鑫 , 邹莉 , 杨得锁 , 冯海涛 . 四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu2＋[J]. 有机化学, 2024 , 44(8) : 2581 -2587 . DOI: 10.6023/cjoc202403043

Abstract

The fluorescent probe TPE-Py was designed and synthesized, and its structure was confirmed by NMR and HRMS. The recognition properties of probe TPE-Py for metal ions have been studied through fluorescence spectrophotometry and cell imaging experiments in HeLa cells. The results showed that TPE-Py had good selectivity and sensitivity for Cu2＋. Among various metal ions, TPE-Py only showed exclusive fluorescence turn-off sensing on Cu2＋ in H2O/THF (V∶V=9∶1). The results of cell imaging experiments showed that the probe TPE-Py could detect Cu2＋ in lipid droplets of cells.

Key words： aggregation-induced emission; fluorescent sensor; ion recognition; cell imaging

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